55470-10-5Relevant academic research and scientific papers
Experimental and computational studies of epithelial transport of mefenamic acid ester prodrugs
Wiwattanawongsa, Kamonthip,Tantishaiyakul, Vimon,Lomlim, Luelak,Rojanasakul, Yon,Pinsuwan, Sirirat,Keawnopparat, Sanae
, p. 721 - 727 (2007/10/03)
Purpose. A series of ester derivatives of mefenamic acid were synthesized with the aim of suppressing local gastrointestinal toxicity of mefenamic acid. A computational method was used to assist the design of the prodrug and to gain insights into the stru
New esters of N arylanthranilic acids
Salimbeni,Manghisi,Magistretti
, p. 276 - 286 (2007/10/06)
A series of acyloxy and alkyloxymethyl esters of meclofenamic, flufenamic and mefenamic acids has been synthesized and its antiinflammatory, analgesic and antipyretic activities have been compared with those of the corresponding acids and the methyl, β,γ isopropylidenedioxypropyl, and N,N diethylaminoethyl esters. The acyloxy and alkyloxymethyl esters are the most interesting compounds, because they possess pharmacological activity of the same order as that of the corresponding acids and a lower toxicity. The ethoxymethyl ester of N (2,6 dichloro m tolyl)anthranilic acid is presently under clinical investigation.
