55476-33-0 Usage
General Description
5-(2'-HYDROXYETHYL)AMINOURACIL, also known as HEAU, is a chemical compound belonging to the class of aminouracils. It contains a uracil base with a hydroxyl group and an aminoethyl group attached to the fifth position. It is a potent inhibitor of thymidylate synthase, an enzyme involved in DNA synthesis, making it a potential candidate for anti-cancer therapy. HEAU has been studied for its ability to block cellular proliferation and induce apoptosis in cancer cells. Additionally, it has been identified as a potential radioprotector, with the ability to protect cells from radiation-induced damage. 5-(2'-HYDROXYETHYL)AMINOURACIL has shown promise in preclinical studies and is undergoing further investigation for its potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 55476-33-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,7 and 6 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55476-33:
(7*5)+(6*5)+(5*4)+(4*7)+(3*6)+(2*3)+(1*3)=140
140 % 10 = 0
So 55476-33-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H9N3O3/c10-2-1-7-4-3-8-6(12)9-5(4)11/h3,7,10H,1-2H2,(H2,8,9,11,12)
55476-33-0Relevant articles and documents
Novel 5-(N -alkylaminouracil) acyclic nucleosides
Boncel, Sawomir,Gondela, Andrzej,McZka, MacIej,Tuszkiewicz-Kuznik, Magdalena,Grec, Przemysaw,Hefczyc, Barbara,Walczak, Krzysztof
experimental part, p. 603 - 610 (2011/04/12)
Protocols for the two-step syntheses of new 5-(N-hydroxyalkyl- and 5-N-benzylamino)uracil acyclic nucleosides bearing various functional groups (alkoxy/hydroxy and cyano/ester) are presented. Two groups of the title compounds were synthesised via aminolysis of 5-bromouracil and, subsequently, either coupling with an alkylating agent (2-chloromethoxyethyl acetate), or Michael-type addition to acrylonitrile/methyl acrylate. The reverse sequences for both syntheses were also studied. The target molecules were designed as non-nucleoside reverse transcriptase inhibitors (NNRTI) and are analogues of 1-(hydroxyethoxymethyl)-6-thiophenylthymine (HEPT) and 3-benzyl-1- cyanomethyluracils. The obtained compounds will be used in screening tests for anti-HIV-1 activity. Georg Thieme Verlag Stuttgart New York.
