55476-33-0 Usage
Uses
Used in Pharmaceutical Industry:
5-(2'-HYDROXYETHYL)AMINOURACIL is used as an anti-cancer agent for its capacity to inhibit thymidylate synthase, thereby disrupting DNA synthesis and blocking cellular proliferation in cancer cells. It is particularly effective in inducing apoptosis, which makes it a promising candidate for the development of new cancer treatments.
Used in Radioprotection Applications:
HEAU is used as a radioprotector to safeguard cells from radiation-induced damage. Its potential to mitigate the harmful effects of radiation on both healthy and cancerous cells is significant, especially in the context of cancer radiotherapy where minimizing damage to surrounding tissues is crucial.
Used in Cancer Research:
In the field of cancer research, 5-(2'-HYDROXYETHYL)AMINOURACIL is utilized for its potential to advance understanding of the mechanisms underlying cancer cell proliferation and apoptosis. Its role in preclinical studies provides valuable insights into the development of novel therapeutic strategies for cancer treatment.
Used in Drug Development:
HEAU is employed in drug development as a lead compound for the creation of new pharmaceuticals targeting cancer. Its unique properties and mechanisms of action offer opportunities for the design of innovative drugs that could improve patient outcomes in cancer treatment.
Used in Radiotherapy Enhancement:
In radiotherapy, 5-(2'-HYDROXYETHYL)AMINOURACIL is used to enhance the effectiveness of radiation treatments. Its radioprotective properties may allow for higher doses of radiation to be administered to cancer cells while minimizing damage to healthy cells, potentially improving treatment efficacy and patient safety.
Check Digit Verification of cas no
The CAS Registry Mumber 55476-33-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,7 and 6 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55476-33:
(7*5)+(6*5)+(5*4)+(4*7)+(3*6)+(2*3)+(1*3)=140
140 % 10 = 0
So 55476-33-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H9N3O3/c10-2-1-7-4-3-8-6(12)9-5(4)11/h3,7,10H,1-2H2,(H2,8,9,11,12)
55476-33-0Relevant academic research and scientific papers
Novel 5-(N -alkylaminouracil) acyclic nucleosides
Boncel, Sawomir,Gondela, Andrzej,McZka, MacIej,Tuszkiewicz-Kuznik, Magdalena,Grec, Przemysaw,Hefczyc, Barbara,Walczak, Krzysztof
experimental part, p. 603 - 610 (2011/04/12)
Protocols for the two-step syntheses of new 5-(N-hydroxyalkyl- and 5-N-benzylamino)uracil acyclic nucleosides bearing various functional groups (alkoxy/hydroxy and cyano/ester) are presented. Two groups of the title compounds were synthesised via aminolysis of 5-bromouracil and, subsequently, either coupling with an alkylating agent (2-chloromethoxyethyl acetate), or Michael-type addition to acrylonitrile/methyl acrylate. The reverse sequences for both syntheses were also studied. The target molecules were designed as non-nucleoside reverse transcriptase inhibitors (NNRTI) and are analogues of 1-(hydroxyethoxymethyl)-6-thiophenylthymine (HEPT) and 3-benzyl-1- cyanomethyluracils. The obtained compounds will be used in screening tests for anti-HIV-1 activity. Georg Thieme Verlag Stuttgart New York.
