55480-45-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(N-METHYLPIPERAZINE)-PROPAN-1-OIC ACID HYDROCHLORIDE SALT is used as a chemical intermediate for the synthesis of pharmaceuticals targeting a range of biological pathways. Its unique molecular structure allows for the development of drugs with potential therapeutic applications.
The hydrochloride salt form of the compound is particularly advantageous due to its increased solubility and stability, which can be critical factors in the formulation and efficacy of pharmaceutical products. This makes it a preferred choice for researchers and chemists working on drug development projects.

InChI:InChI=1/C8H16N2O2/c1-9-4-6-10(7-5-9)3-2-8(11)12/h2-7H2,1H3,(H,11,12)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 7148-05-2 ethyl 3-(4-methylpiperazin-1-yl)propanoate 

Downstream Products

• 1309863-65-7 N'-{2-[(4-methoxy-2-nitrophenyl)thio]phenyl}-3-(4-methylpiperazin-1-yl)propanehydrazide 
• 1309863-66-8 N'-{2-[(2,4-dinitrophenyl)thio]phenyl}-3-(4-methylpiperazin-1-yl)propanehydrazide 
• 1309863-63-5 3-(4-methylpiperazin-1-yl)-N'-{2-[(2-nitrophenyl)thio]phenyl}propanehydrazide 
• 1309863-64-6 N'-{2-[(4-chloro-2-nitrophenyl)thio]phenyl}-3-(4-methylpiperazin-1-yl)propanehydrazide 
• 1309846-23-8 (Z)-(4-((5-(5-chloro-2-fluorophenylamino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)-2,5-dioxoimidazolidin-1-yl)methyl 3-(4-methylpiperazin-1-yl)propanoate 
• 1446981-12-9 N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)-ureido)phenylamino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide trifluoroacetic acid 
• 1443239-62-0 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4R)-4-{3-[2-(4-methyl-piperazin-1-yl)-ethyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea formate 
• 1431470-05-1 N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-3-(4-methylpiperazin-1-yl)propionamide 

Relevant academic research and scientific papers

N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

We have previously reported the multifunctional profile of N-(3-chloro-10H-phenothiazin-10-yl)-3-(dimethylamino)propanamide (1) as an effective neuroprotectant and selective butyrylcholinesterase inhibitor. In this paper, we have developed a series of N-acylaminophenothiazines obtained from our compound library or newly synthesised. At micro- and sub-micromolar concentrations, these compounds selectively inhibited butyrylcholinesterase (BuChE), protected neurons against damage caused by both exogenous and mitochondrial free radicals, showed low toxicity, and could penetrate into the CNS. In addition, N-(3-chloro-10H-phenothiazin-10-yl)-2-(pyrrolidin-1-yl) acetamide (11) modulated the cytosolic calcium concentration and protected human neuroblastoma cells against several toxics, such as calcium overload induced by an l-type Ca2+-channel agonist, tau-hyperphosphorylation induced by okadaic acid and Aβ peptide.