55480-45-0

Basic information

• Product Name: 3-(N-METHYLPIPERAZINE)-PROPAN-1-OIC ACID HYDROCHLORIDE SALT
• Synonyms: RARECHEM AL BO 2379;TIMTEC-BB SBB010546;BUTTPARK 82\11-37;CHEMBRDG-BB 4010145;AKOS 93672;AKOS BBS-00002531;AKOS BB-5247;4-METHYL-1-PIPERAZINEPROPANOIC ACID
• CAS NO: 55480-45-0
• Molecular Formula: C₈H₁₆N₂O₂
• Molecular Weight: 208.69
• Product Categories: PIPERIDINE;piperazines
• Mol File: 55480-45-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 305.5 °C at 760 mmHg
• Flash Point: 138.6 °C
• Appearance: /
• Density: 1.095g/cm³
• Vapor Pressure: 0.000186mmHg at 25°C
• Refractive Index: 1.494
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 3-(N-METHYLPIPERAZINE)-PROPAN-1-OIC ACID HYDROCHLORIDE SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N-METHYLPIPERAZINE)-PROPAN-1-OIC ACID HYDROCHLORIDE SALT(55480-45-0)
• EPA Substance Registry System: 3-(N-METHYLPIPERAZINE)-PROPAN-1-OIC ACID HYDROCHLORIDE SALT(55480-45-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 55480-45-0(Hazardous Substances Data)

Usage

General Description

3-(N-Methylpiperazine)-propan-1-oic acid hydrochloride salt is a chemical compound that contains the molecular structure of a propanoic acid derivative substituted with an N-methylpiperazine group. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The hydrochloride salt form of the compound enhances its solubility in water and improves its stability, making it more suitable for certain applications. This chemical may have potential applications in the pharmaceutical industry as a building block for the synthesis of drugs targeting various biological pathways. However, it is important to handle this compound with care and adhere to proper safety precautions when working with it in a laboratory setting.

InChI:InChI=1/C8H16N2O2/c1-9-4-6-10(7-5-9)3-2-8(11)12/h2-7H2,1H3,(H,11,12)

Upstream product

• 7148-05-2 ethyl 3-(4-methylpiperazin-1-yl)propanoate 
• 109-01-3 1-methyl-piperazine 

Downstream Products

• 1309863-65-7 N'-{2-[(4-methoxy-2-nitrophenyl)thio]phenyl}-3-(4-methylpiperazin-1-yl)propanehydrazide 
• 1309863-66-8 N'-{2-[(2,4-dinitrophenyl)thio]phenyl}-3-(4-methylpiperazin-1-yl)propanehydrazide 
• 1443239-62-0 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4R)-4-{3-[2-(4-methyl-piperazin-1-yl)-ethyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea formate 
• 1309863-64-6 N'-{2-[(4-chloro-2-nitrophenyl)thio]phenyl}-3-(4-methylpiperazin-1-yl)propanehydrazide 
• 1309863-63-5 3-(4-methylpiperazin-1-yl)-N'-{2-[(2-nitrophenyl)thio]phenyl}propanehydrazide 
• 1309846-23-8 (Z)-(4-((5-(5-chloro-2-fluorophenylamino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)-2,5-dioxoimidazolidin-1-yl)methyl 3-(4-methylpiperazin-1-yl)propanoate 
• 1446981-12-9 N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)-ureido)phenylamino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide trifluoroacetic acid 
• 1431470-05-1 N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-3-(4-methylpiperazin-1-yl)propionamide 

Relevant articles and documents

N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

We have previously reported the multifunctional profile of N-(3-chloro-10H-phenothiazin-10-yl)-3-(dimethylamino)propanamide (1) as an effective neuroprotectant and selective butyrylcholinesterase inhibitor. In this paper, we have developed a series of N-acylaminophenothiazines obtained from our compound library or newly synthesised. At micro- and sub-micromolar concentrations, these compounds selectively inhibited butyrylcholinesterase (BuChE), protected neurons against damage caused by both exogenous and mitochondrial free radicals, showed low toxicity, and could penetrate into the CNS. In addition, N-(3-chloro-10H-phenothiazin-10-yl)-2-(pyrrolidin-1-yl) acetamide (11) modulated the cytosolic calcium concentration and protected human neuroblastoma cells against several toxics, such as calcium overload induced by an l-type Ca2+-channel agonist, tau-hyperphosphorylation induced by okadaic acid and Aβ peptide.