55482-04-7Relevant academic research and scientific papers
Synthesis and characterization of 5-hydroxymethyl-5-methyl-pyrroline N-oxide and its derivatives
Stolze, Klaus,Rohr-Udilova, Natascha,Patel, Anjan,Rosenau, Thomas
body text, p. 985 - 993 (2011/03/18)
Synthesis and spin trapping behavior of three novel DMPO derivatives, namely 5-hydroxymethyl-5-methyl-pyrroline N-oxide (HMMPO), 5-(2-furanyl)- oxymethyl-5-methyl-pyrroline N-oxide (FMMPO), and 5-(2-pyranyl)-oxymethyl-5- methyl-pyrroline N-oxide (PMMPO) towards different oxygen- and carbon-centered radicals are described. The stabilizing effect of a series of cyclodextrins on the superoxide adducts was tested.
Probing the surface of transition-metal nanocrystals by chemiluminesence
Krylova, Galyna,Dimitrijevic, Nada M.,Talapin, Dmitri V.,Guest, Jeffrey R.,Borchert, Holger,Lobo, Arun,Rajh, Tijana,Shevchenko, Elena V.
experimental part, p. 9102 - 9110 (2010/08/21)
We propose a simple chemiluminescence (CL) method for investigation of the surface of Co-based nanocrystals (NCs). Using a combination of CL and spin-trap electron paramagnetic resonance techniques, we systematically studied the generation of reactive oxygen species (ROS) at the surface of differently sized CoPt3 spherical NCs and CoPt3/Au nanodumbbells. We have shown that differently sized CoPt3 NCs can promote the formation of ROS and as a result can lead to the oxidation of luminol accompanied by the emission of the light. CL allows monitoring the stability of transition-metal-based NCs against oxidation and dissolution. We found by CL that cobalt ions slowly leach from the surface of CoPt3 NCs even under very mild conditions; however, the amount of the leached cobalt ions does not exceed the maximal concentration of cobalt at the NC surface indicating that only surface atoms can go into solution.
Mechanistic studies on the formation of aminoxyl radicals from 5,5-dimethyl-1-pyrroline-N-oxide in Fenton systems. Characterization of key precursors giving rise to background ESR signals
Makino, Keisuke,Hagi, Akifumi,Ide, Hiroshi,Murakami, Akira,Nishi, Masatoshi
, p. 2818 - 2827 (2007/10/02)
To assign unidentified ESR signals obtained in a Fenton system with a spin trap, 5,5-dimethyl-pyrroline-N-oxide (DMPO), fundamental reactions of DMPO have been thoroughly investigated.When the concentration of Fe(2+) in Fenton systems exceeded 1percent of that of DMPO, background ESR signals totally distinguishable from 2-hydroxy-5,5-dimethyl-1-pyrollidinyloxy (DMPO-OH) appeared, and simultaneously absorbance at 520 nm increased, which was characteristic of hydroxamic acids complexed with Fe(3+).To prove the postulated formation of hydroxamic acid as a key intermediate, DMPO was subjected to Fenton reaction or was treated with Fe(3+) in aqueous solution to produce DMPO-OH (Makino et al.Biochem.Biophy.Res.Commun. 172, 1073 (1990)), and a major product was was isolated by RPLC.Based on (1)H, (13)C NMR and MS measurements, the structure of the major product was assigned to 1-hydroxy-5,5-dimethyl-1-pyrrolid-2-one (HDMPN) having a hydroxamic acid structure.Temperature dependence of NMR spectra and careful analysis of the fragmentation patterns in MS further revealed that HDMPN was present in equilibrium with 2-hydroxy-5,5-dimethyl-1-pyrroline-N-oxide (HDMPO), a tautomer of HDMPN.It has also been shown that the oxidation of DMPO yielding HDMPN and HDMPO occurs via DMPO-OH and is driven by Fe(3+).These oxidation products (HDMPN and HDMPO) were readily converted to the corresponding ESR visible aminoxyl radicals by oxidation and .OH addition in aqueous solution, respectively, and superimposition of the ESR signals arising from these radicals accounts for the background signals observed in Fenton systems with DMPO as spin trap.
