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Nepetoidin B is a natural product isolated from the roots of Nepeta laevigata, characterized by its diterpene skeleton similar to other nepetoidins. Nepetoidin B demonstrates moderate cytotoxicity against various human cancer cell lines and significant antibacterial activity against Staphylococcus aureus and Escherichia coli, positioning it as a potential candidate for both cancer treatment and antibacterial therapy.

55486-06-1

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55486-06-1 Usage

Uses

Used in Cancer Treatment:
Nepetoidin B is used as an anticancer agent for its moderate cytotoxicity against several human cancer cell lines, offering potential for further development in this area.
Used in Antibacterial Therapy:
Nepetoidin B is used as an antibacterial agent for its significant activity against Staphylococcus aureus and Escherichia coli, indicating its potential in combating bacterial infections.

Check Digit Verification of cas no

The CAS Registry Mumber 55486-06-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,8 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 55486-06:
(7*5)+(6*5)+(5*4)+(4*8)+(3*6)+(2*0)+(1*6)=141
141 % 10 = 1
So 55486-06-1 is a valid CAS Registry Number.

55486-06-1Upstream product

55486-06-1Downstream Products

55486-06-1Relevant academic research and scientific papers

An efficient synthesis of Nepetoidin B

Xiong, Hangxing,Yang, Sen,Yao, Ming,Zhang, Jingjing

, (2020/09/07)

The synthesis of nepetoidin B from readily and commercially available 3,4-dimethoxybenzaldehyde in an overall yield of 52% is achieved. The present three-step protocol involves Ramirez–Corey–Fuchs reaction, ruthenium-catalyzed anti-Markovnikov addition of a carboxylic acid to a terminal alkyne and demethylation using iodotrimethylsilane (Me3SiI) and quinoline. In this work, the two isomers of (Z, E)- nepetoidin B /(E, E)nepetoidin B and the single isomer of (E, E)- nepetoidin B can be obtained through the demethylation of (Z, E)-5 and (E, E)-5, respectively.

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