55489-59-3Relevant academic research and scientific papers
Combinatorial synthesis of PEG oligomer libraries
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Page/Page column 9, (2010/02/15)
A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.
Lipophilic diesters of chelating agents
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, (2008/06/13)
The invention discloses stable diesters of chelating agents of divalent metal ions, processes for their preparation and pharmaceutical compositions thereof. Most preferred compounds according to the present invention are stable lipophilic diesters comprising a covalent conjugate of a BAPTA and a pharmaceutically acceptable alcohol. The diesters are useful in a method for treating a condition or disease related to an excess of divalent metal ions, and in particular for the treatment of a condition or disease related to elevated levels of intracellular calcium ions, such as in brain or cardiac ischemia, stroke, epilepsy, Alzheimer's disease or cardiac arrhythmia and in open heart surgery.
Synthesis of glycol ethers and their use for intensification of oil recovery
Lebedeva,Mazaev,Tret'yakov
, p. 1415 - 1417 (2007/10/03)
Monoalkyl ethers of ethylene and triethylene glycols were prepared and tested for intensification of oil recovery. The features of oil displacement with aqueous solutions of glycol ethers from bulk models of strata and the effect of glycol ethers on acid treatment of oil-saturated samples were examined. A correlation between the structure of ether and its performance was revealed. The interphase tension at the boundary between the aqueous solution of the glycol ether and kerosene was determined.
Process for preventing consolidation of p-dichlorobenzene
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, (2008/06/13)
A triethylene glycol derivative is added to p-dichlorobenzene so as to prevent consolidation and improve flowability of p-dichlorobenzene.
Topical mosquito repellents VII: Alkyl triethylene glycol monoethers
Johnson,DeGraw,Engstrom,Skinner,Brown,Skidmore,Maibach
, p. 693 - 695 (2007/10/05)
Normal and branched chain aliphatic monoethers of triethylene glycol are effective topical mosquito repellents. In terms of duration of protection, they are generally superior to the corresponding diethylene glycol analogs, and some are superior to diethyltoluamide. The n heptyl monoether of triethylene glycol affords double the protection time of diethyltoluamide under controlled laboratory conditions, and appears to be a useful new mosquito repellent.
