55502-54-0

Upstream product

• 1928-54-7 3,5-Dichlorphenoxy-essigsaeuremethylester 
• 591-35-5 3,5-dichlorophenol 
• 119024-29-2 ethyl 2-(3,5-dichlorophenoxy)acetate 
• 587-64-4 2-(3,5-dichlorophenoxy)acetic acid 

Downstream Products

• 706790-27-4 t-butyl 2-(3,5-dichlorophenoxy)acetate 
• 1226145-00-1 ethyl 4-(3,5-dichlorophenoxy)-3-oxobutanoate 
• 1227692-67-2 5-((3,5-dichlorophenoxy)methyl)-1H-pyrazol-3(2H)-one 
• 1227692-21-8 2-(3,5-dichlorophenoxy)-N-methoxy-N-methylacetamide 

Relevant academic research and scientific papers

Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action

In order to develop a novel herbicide containing the β-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha-1. Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha-1 under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: Potential application for the treatment of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. The arylsulfanyl pyrazolone (ASP) scaffold was one of the active scaffolds identified in a cell-based high throughput screening assay targeting mutant Cu/