55503-31-6

Usage

Uses

Used in Pharmaceutical Industry:
4-HYDROXYTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER is used as an intermediate in the synthesis of pharmaceuticals for its potential role in the treatment of various diseases. Its unique chemical structure allows it to be a key component in the development of new drugs with therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, 4-HYDROXYTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER is utilized as a precursor in the development of new crop protection products. Its properties make it a valuable asset in creating effective and innovative solutions for agricultural challenges.
Used in Organic Chemistry Research:
4-HYDROXYTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER is employed as a building block in the synthesis of more complex organic molecules. Its versatility in organic chemistry contributes to the discovery and creation of novel compounds with potential applications in various industries.
Used in Industrial Product Development:
4-HYDROXYTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER is also used in the production of important industrial products, leveraging its unique properties to enhance the development of new materials and technologies that can address current and future needs across different sectors.

Upstream product

• 59713-52-9 ethyl α-carboethoxy-β-(N-2-thienylammonium) acrylate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 59713-58-5 ethyl 4-chlorothieno<2,3-b>pyridine-5-carboxylate 
• 55503-32-7 4-hydroxythieno<2,3-b>pyridine-5-carboxylic acid 
• 292143-49-8 N-(4-chlorobenzyl)-4-hydroxythieno[2,3-b]pyridine-5-carboxamide 
• 292143-58-9 2-Bromo-N-(4-chlorobenzyl)-4-hydroxythieno[2,3-b]pyridine-5-carboxamide 
• 292144-13-9 rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide 
• 292143-67-0 N-(4-Chlorobenzyl)-2-cyano-4-hydroxythieno[2,3-b]pyridine-5-carboxamide 
• 292143-64-7 N-(4-Chlorobenzyl)-4-hydroxy-2-(3-methoxy-1-propynyl)thieno[2,3-b]pyridine-5-carboxamide 
• 292144-12-8 N-(4-chlorobenzyl)-7-methyl-4-oxo-2-(4-thiomorpholinylmethyl)-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide 
• 292144-21-9 N-(4-Chlorobenzyl)-4-hydroxy-2-(4-morpholinyl-carbonyl)thieno[2,3-b]pyridine-5-carboxamide 
• 292144-22-0 N-(4-Chlorobenzyl)-7-methyl-2-(4-morpholinyl-carbonyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide 
• 292143-83-0 2-[5-{[(4-chlorobenzyl)amino]carbonyl}-2-(3-hydroxy-1-propynyl)-4-oxothieno[2,3-b]pyridin-7(4H)-yl]acetic acid 
• 292143-81-8 N-(4-Chlorobenzyl)-7-[2-(diethylamino)ethyl]-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide hydrochloride 
• 67637-79-0 7-benzyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid 
• 67637-78-9 7-methyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and antiviral activity of new 4-(phenylamino)thieno[2,3-b] pyridine derivatives

Several new 4-(phenylamino)thieno[2,3-6]pyridines (6a-e) were synthesized and tested against herpes simplex virus type 1 (HSV-1). For the first time one compound (6a) of this heterocyclic system showed 86% of inhibitory indicating that these compounds retain antiviral potency in comparison to the parent pirazolo-pyridine derivatives.

Heterocyclic fused pyridone carboxylic acid M1 positive allosteric modulators

The phenyl ring in a series of quinolone carboxylic acid M1 positive allosteric modulators was replaced with a variety of heterocycles in order to reduce protein plasma binding and enhance CNS exposure.

4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases

A novel series of 4-oxo-4,7-dihydrothieno[2,3-6]pyridine-5-carboxamides have been identified as potential antivirals against human herpesvirus infections resulting from human cytomegalovirus (HCMV), herpes simplex virus type 1 (HSV-1), and varicella-zoster virus (VZV). Compounds 10c and 14 demonstrated broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, and VZV. High specificity for the viral polymerases was observed compared to human α polymerase. The antiviral activity of 10c and 14, as determined by plaque reduction assay, was comparable or superior to that of existing antiherpes drugs, ganciclovir (for HCMV) and acyclovir (for HSV-1 and VZV). Drug resistance to compound 14 correlated to point mutations in conserved domain III of the herpesvirus DNA polymerase, but these mutations do not confer resistance to existing nucleoside therapy. In addition, compound 14 maintained potent antiviral activity against acyclovir-resistant HSV-1 strains. Substitution to the pyridone nitrogen (N7) was found to be critical for enhanced in vitro antiviral activity.

Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6 and X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

HETEROARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS

The present invention provides a compound of formula (I), which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.