55513-18-3 Usage
Chemical class
Piperazine derivative
Explanation
It belongs to the class of organic compounds known as piperazines, which are heterocyclic compounds containing a six-membered ring with two nitrogen atoms.
Explanation
The piperazine ring has a 5-chlorothien-2-ylmethyl group attached to it, which is a chlorine-containing thiophene ring connected to a methyl group.
Explanation
The compound has potential applications in the field of medicinal chemistry, particularly in the development of pharmaceutical drugs.
Explanation
The addition of the 5-chlorothien-2-ylmethyl group to the piperazine structure may allow the compound to target specific biological pathways, making it a potential candidate for drug development.
Explanation
More research and studies are required to fully understand the potential applications, properties, and mechanisms of action of 1-[(5-CHLOROTHIEN-2-YL)METHYL]PIPERAZINE.
Explanation
The chemical formula represents the composition of the compound, indicating the number of carbon (C), hydrogen (H), chlorine (Cl), nitrogen (N), and sulfur (S) atoms present in the molecule.
Explanation
The molecular weight is the sum of the atomic weights of all the atoms in the molecule, which can be used to calculate the mass of a specific quantity of the compound.
Explanation
The compound is likely to exist in a solid or crystalline form at room temperature, although the exact physical state may depend on various factors such as temperature and pressure.
Explanation
The solubility of 1-[(5-CHLOROTHIEN-2-YL)METHYL]PIPERAZINE in different solvents (e.g., water, organic solvents) may vary and can be influenced by factors such as temperature and the compound's chemical structure.
Explanation
The compound's stability can be affected by various factors, including exposure to light, heat, or moisture, which may lead to degradation or changes in its properties. Proper storage and handling are essential to maintain the compound's integrity.
Structure
5-chlorothien-2-ylmethyl group attached to the piperazine ring
Potential use
Medicinal chemistry
Biological pathways
Targeting specific pathways
Research and studies
Further investigation needed
Molecular weight
Approximately 225.74 g/mol
Appearance
Solid or crystalline form
Solubility
Solvent-dependent
Stability
May be sensitive to light, heat, or moisture
Check Digit Verification of cas no
The CAS Registry Mumber 55513-18-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,5,1 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 55513-18:
(7*5)+(6*5)+(5*5)+(4*1)+(3*3)+(2*1)+(1*8)=113
113 % 10 = 3
So 55513-18-3 is a valid CAS Registry Number.
55513-18-3Relevant academic research and scientific papers
A convenient synthesis by microwave heating and pharmacological evaluation of novel benzoyltriazole and saccharine derivatives as 5-HT1A receptor ligands
Caliendo, Giuseppe,Fiorino, Ferdinando,Perissutti, Elisa,Severino, Beatrice,Scolaro, Daniela,Gessi, Stefania,Cattabriga, Elena,Borea, Pier Andrea,Santagada, Vincenzo
, p. 15 - 28 (2007/10/03)
A series of novel 1,2,3-4-benzoyltriazole and saccharine derivatives were designed and synthesized by microwave heating. They were evaluated on a battery of receptors, including serotonin 5-HT1A, 5-HT2A and 5-HT2C, and the most interesting compounds were further evaluated on dopaminergic D1, D2 and adrenergic α1, α2 receptors. Conventional and microwave heating of the reactions were compared. Synthesis by microwave heating gave the desired compounds in better yields than those obtained by conventional heating. The overall times for the syntheses were considerably reduced. All compounds displayed moderate affinity for 5-HT1A receptor. The most interesting compound 33 showed a high affinity (Ki=93 nM) which was combined with no affinity on the other receptors considered.
Synthesis by microwave irradiation and binding properties of novel 5-HT1A receptor ligands
Caliendo, Giuseppe,Fiorino, Ferdinando,Perissutti, Elisa,Severino, Beatrice,Gessi, Stefania,Cattabriga, Elena,Borea, Pier Andrea,Santagada, Vincenzo
, p. 873 - 886 (2007/10/03)
This work reports the synthesis by microwave irradiation and the binding tests on the 5-HT1A, 5-HT2A and 5-HT2C receptors of new substituted piperazines in order to identify selective ligands for 5-HT1A subtype receptor. Conventional heating and microwave irradiation of the reactions was compared. Synthesis by microwave irradiation gave the desired compounds in better yields than those obtained by conventional heating. The overall times for the syntheses were considerably reduced. Some resulting active compounds (29 and 39) were characterised by a good selectivity profile for the 5-HT1A subtype receptor. The more active compounds were selected and further evaluated for their binding affinities on D1, D2 dopaminergic and α1, α2 adrenergic receptors. The compound with higher affinity and selectivity for the 5-HT1A over all the considered receptors was the 3-{4-[4-(1,2,3,4-tetrahydronaphthyl)-1-piperazinyl]butan}-benzotriazinone (-)29 (5-HT1A Ki=36 nM, other receptors not active).
