55514-13-1Relevant academic research and scientific papers
Rhodacyanine dyes as antimalarials. 1. Preliminary evaluation of their activity and toxicity
Takasu, Kiyosei,Inoue, Hiroshi,Kim, Hye-Sook,Suzuki, Makoto,Shishido, Tadao,Wataya, Yusuke,Ihara, Masataka
, p. 995 - 998 (2002)
The rhodacyanine dye MKT-077 (1), a potent antitumor agent, was found to possess strong in vitro activity against Plasmodium falciparum and a low cytotoxicity. Several new rhodacyanine dyes related to 1, containing a variety of linked heterocyclic moieties, were synthesized, and their antimalarial potencies were evaluated. The synthetic rhodacyanines were found to have EC50 values against P. falciparum in vitro in the range of 4-300 nM. Several compounds in this series have remarkable selective toxicity profiles (> 100).
HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS
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, (2008/06/13)
Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. In certain embodiments, the compounds are thiazolidinone derivatives.
