555153-75-8Relevant articles and documents
Catalytic asymmetric synthesis of quaternary carbons bearing two aryl substituents. Enantioselective synthesis of 3-alkyl-3-aryl oxindoles by catalytic asymmetric intramolecular Heck reactions
Dounay, Amy B.,Hatanaka, Keiko,Kodanko, Jeremy J.,Oestreich, Martin,Overman, Larry E.,Pfeifer, Lance A.,Weiss, Matthew M.
, p. 6261 - 6271 (2007/10/03)
A practical sequence involving three consecutive palladium (0)-catalyzed reactions has been developed for synthesizing 3-alkyl-3-aryloxindoles in high enantiopurity. The Heck cyclization precursors 10 and 11a-k are generated in one step by chemoselective