555154-35-3Relevant academic research and scientific papers
4-alkylthio polysubstituted thiophene derivative and synthesis thereof
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Paragraph 0035-0037, (2020/05/01)
The invention discloses a method for synthesizing a 4-alkylthio polysubstituted thiophene derivative with potential biological activity. According to the invention, the 4-alkylthio polysubstituted thiophene derivative is generated in one step through intermolecular in-situ generation of sulfur ylide and intramolecular cyclization reaction by using a 3,3-dialkylthiomethylene-1,3-dicarbonyl compoundwith characteristics of easy preparation, structural diversity and multiple reaction centers and a diazo compound as raw materials, has a certain potential pharmaceutical activity, and can be furtherconverted into a functional product. The method has the advantages of easily available raw materials, simple operation, mild synthesis reaction conditions, high reaction efficiency, and diversity offunctional groups.
A convenient synthesis of 2,3,4,5-functionalised thieno[2,3-b]thiophenes
Sommen, Geoffroy,Comel, Alain,Kirsch, Gilbert
, p. 735 - 741 (2007/10/03)
A two steps simple synthesis of 2,3,4,5-functionalised thieno[2,3-b]thiophenes 2-6 from ketene dimethylthioacetals is described.
