55516-35-3Relevant academic research and scientific papers
PREPARATION OF PROSTAGLANDIN DERIVATIVES
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Page/Page column 19, (2012/02/05)
A process for preparing the prostaglandin derivatives is provided, wherein the benzoyl and p-nitrobenzoyl groups are used as the hydroxyl protective groups. A pharmaceutical composition comprising the prostaglandin derivatives is also provided.
Diastereoselective reduction of the enone intermediate of Travoprost
Aswathanarayanappa, C.,Bodke, Yadav D.,Bheemappa, E.
experimental part, p. 1085 - 1087 (2011/12/21)
A scalable process for the diastereoselective reduction of the prochiral enone intermediate 1 has been developed with DEANB/(R)-methyl CBS as reducing agent, to obtain the key intermediate alcohol 15R-isomer 2, used in a process for the manufacture of Travoprost (3). Various advantages of this process against the DMSB reduction assisted by (R)-methyl CBS have been studied. Specific comparison has been made to highlight the salient features of the chosen process on yield and optical purity with those of the DMSB reduction.
Improved Process for the Production of Prostaglandins and Prostaglandin Analogs
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Page/Page column 54, (2010/01/29)
The present invention relates to an improved process for the production of prostaglandins and prostaglandin analogs. In particular, this invention relates to the production of prostaglandins of the PGF2α-series, including latanoprost, travoprost, and bimatoprost, which are active pharmaceutical ingredients used for the reduction of elevated intraocular pressure in patients with glaucoma and ocular hypertension.
Enzymatic transformation of a prostaglandin (bimatoprost) intermediate
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Page/Page column 6-7, (2008/06/13)
A method for the selective enzymatic acetylation of a bimatoprost intermediate is provided.
