5552-83-0Relevant academic research and scientific papers
PYRIDAZINE COMPOUND AND USE THEREOF
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Page/Page column 38, (2008/12/07)
A pyridazine compound of the formula: has an excellent plant disease controlling effect.
Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists
Jiang, Jinlong,DeVita, Robert J.,Goulet, Mark T.,Wyvratt, Matthew J.,Lo, Jane-L.,Ren, Ning,Yudkovitz, Joel B.,Cui, Jisong,Yang, Yi T.,Cheng, Kang,Rohrer, Susan P.
, p. 1795 - 1798 (2007/10/03)
Syntheses and structure-activity relationships of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists are described. Some of substituents on the piperidine ring that were investigated included a fused phenyl group, a
Reductive Amination of Ethynylpyridines with Sodium Cyanoborohydride
Sakamoto, Takao,Nagata, Hideo,Kondo, Yoshinori,Sato, Kaori,Yamanaka, Hiroshi
, p. 4866 - 4872 (2007/10/02)
In order to investigate the structure-activity relationship of betahistine derivatives, a general synthesis of methylated 2-(2-methylaminoethyl)pyridines was developed based on the addition of methylamine hydrochloride to methylated 2-ethynylpyridines under reductive conditions.In addition, the scope and limitations of the reductive addition were briefly examined.For example, the reaction proceeded smoothly with p-nitrophenylacetylene, whereas phenylacetylene itself did not react with methylamine.Keywords - ethynylpyridine; sodium cyanoborohydride; reductive amination; betahistine; palladium-catalyzed reaction; ethyl pyridineacetate; 2-(2-pyridyl)ethylamine
