5553-61-7Relevant academic research and scientific papers
Synthesis, antitumor evaluation and crystal structure of hydroxyurea derivatives
Mai, Xi,Lu, Xiaosan,Xia, Hongying,Cao, Yusheng,Liao, Yijing,Lv, Xiaolan
experimental part, p. 94 - 97 (2010/04/26)
A series of hydroxyurea derivatives have been synthesized and elucidated by means of FT-IR, 1H-, 13C-NMR and MS. The exact stereostructures of representative compounds have been determined by X-ray crystal structure analysis. In the crystals, inversion dimers linked by pairs of N-H...O hydrogen bonds occurred, and further N-H...O links led to chains of molecules. In vitro antitumor activities against Tca8113 human tongue cancer cells and L1210 murine leukemia cells were evaluated. A total of 8 of the 12 compounds had higher inhibitory activities than hydroxyurea against L1210 cells. Among them, the most promising compounds were 3e, 3d, 3a and 2d.
