55541-30-5

Basic information

• Product Name: 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)
• Synonyms: 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate);DXMdipropionate;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] propanoate;(11β,16α)-9-Fluoro-11-hydroxy-16-Methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione;MethaderM
• CAS NO: 55541-30-5
• Molecular Formula: C₂₈H₃₇FO₇
• Molecular Weight: 504.59
• EINECS: 259-699-8
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 55541-30-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: approximate 205℃
• Boiling Point: 603.2±55.0 °C(Predicted)
• Appearance: /
• Density: 1.1481 (estimate)
• PKA: 12.87±0.70(Predicted)
• CAS DataBase Reference: 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)(CAS DataBase Reference)
• NIST Chemistry Reference: 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)(55541-30-5)
• EPA Substance Registry System: 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)(55541-30-5)

Safety Data

• Hazardous Substances Data: 55541-30-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 55541-30-5 differently. You can refer to the following data:
1. 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate) is a corticosteroid used in dermatology as a topical vasoconstrictor
2. A corticosteroid used in dermatology as a topical vasoconstrictor.

Downstream Products

• 6762-51-2 C₂₂H₂₇FO₄ 
• 3793-10-0 dexamethasone 21-propionate 

Relevant articles and documents

Novel process for the preparation of steroidal esters

A process for the preparation of corticosteriod esters of the formula STR1 in which ---- signifies that a double bond can be present; X is hydrogen, chlorine or fluorine; R1 is hydrogen, fluorine, chlorine or methyl, which may be either α or β; R2 is halogen, oxo or hydroxyl; or R3 is hydrogen, α-methyl or β-methyl; or R2 and X jointly form an epoxide group; R4 is an acyl group of the formula RCO, in which R is one of the following (i) an alkyl group containing 1 to 16 carbon atoms, whether straight-chained, branched or cyclic; (ii) an aralkyl group of 7 to 8 carbon atoms; (iii) a phenyl group; R5 is hydroxyl or R6 ; where R6 is hydrogen, one or two halogen atom substituents or OR7, where R7 is an acyl group of the formula R'CO in which R', which can be identical or different to R in the same molecule, is one of the following: (i) an alkyl group of 1 to 16 carbon atoms, whether straight-chained, branched or cyclic; (ii) an aralkyl group of 7 to 8 carbon atoms; or (iii) a phenyl group. which comprises esterifying a compound of the formula STR2 wherein X, R1, R3 and R5 are as defined above, and R8 is trihaloacetate, halogen or oxo, or jointly forms an epoxide group with X; at the 17-position only, or at the 17- and 21-positions when R5 in formula III is hydroxyl, the said esterification being carried out with the anhydride of the acid containing the group desired.