55579-69-6

Usage

Uses

Used in Pharmaceutical Research:
5-(4-Trifluoromethyl-phenyl)-cyclohexane-1,3-dione is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its unique structure and potential biological activities, such as antioxidant and anti-inflammatory properties, make it a promising candidate for drug development.
Used in Organic Synthesis:
5-(4-Trifluoromethyl-phenyl)-cyclohexane-1,3-dione is used as a key building block in the synthesis of complex organic molecules. Its aromatic nature and presence of a carbonyl group make it suitable for various chemical reactions, allowing for the creation of a wide range of organic compounds.
Used in Antioxidant and Anti-inflammatory Applications:
Due to its potential antioxidant and anti-inflammatory properties, 5-(4-Trifluoromethyl-phenyl)-cyclohexane-1,3-dione may be used in the development of therapeutic agents for treating conditions associated with oxidative stress and inflammation.

InChI:InChI=1/C13H11F3O2/c14-13(15,16)10-3-1-8(2-4-10)9-5-11(17)7-12(18)6-9/h1-4,9H,5-7H2

Upstream product

• 80992-93-4 4-(4-trifluoromethylphenyl)but-3-en-2-one 
• 455-19-6 4-Trifluoromethylbenzaldehyde 

Downstream Products

• 138793-82-5 4-hydroxy-2-(4-chlorophenyl)-7-(4-trifluoromethylphenyl)-5,6,7,8-tetrahydroquinolin-5-one 
• 138793-83-6 4-hydroxy-3-(4-chlorophenyl)-7-(4-trifluoromethylphenyl)-5,6,7,8-tetrahydroquinolin-5-one 
• 138793-84-7 5-hydroxy-1-methyl-2-(4-chlorophenyl)-7-(4-trifluoromethylphenyl)-1,4-dihydroquinolin-4-one 
• 138793-85-8 1-methyl-2-(4-chlorophenyl)-7-(4-trifluoromethylphenyl)-1,4,5,6,7,8-hexahydroquinolin-4,5-dione 
• 144155-03-3 3-(4-Trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 144155-27-1 6-Chloro-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 144155-10-2 7-Fluoro-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 144155-02-2 7-Bromo-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 144128-97-2 7-Chloro-6-fluoro-10-hydroxy-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 144155-08-8 5,7-Dichloro-3,4-dihydro-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione 
• 144155-01-1 5,7-Dibromo-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 75618-36-9 7,10-Dihydroxy-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 75618-35-8 8-Chloro-7,10-dihydroxy-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 144128-98-3 7,8-Dichloro-10-hydroxy-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 

Relevant academic research and scientific papers

SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.