5558-48-5Relevant academic research and scientific papers
HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives
Wang, Guangyi,He, Yanzhen,Sun, Jun,Das, Debasis,Hu, Mougang,Huang, Jianhua,Ruhrmund, Donald,Hooi, Lisa,Misialek, Shawn,Ravi Rajagopalan,Stoycheva, Antitsa,Buckman, Brad O.,Kossen, Karl,Seiwert, Scott D.,Beigelman, Leonid
scheme or table, p. 4476 - 4479 (2010/04/05)
2-(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives as potential anti-HCV drugs targeting NS5B polymerase have been investigated. Their synthesis, HCV NS5B polymerase inhibition and replicon activity are discussed.
Novel Inhibitors of Hepatitis C Virus Replication
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Page/Page column 48-49, (2009/10/21)
The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
