556053-78-2Relevant academic research and scientific papers
Pyrido[3,4-b]pyrazines. A new application of 2-chloro-3,4-diaminopyridine
Mederski, Werner W. K. R.,Kux, Dieter,Knoth, Markus,Schwarzkopf-Hofmann, Markus J.
, p. 925 - 932 (2007/10/03)
5-Chloropyrido[3,4-b]pyrazines were prepared from 1,2-dicarbonyl compounds and 2-chloro-3,4-diaminopyridine. Condensation of unsymmetrical glyoxals provided a mixture of two regiosiomers with 2-substituted pyrido[3,4-b]-pyrazines as the major product. The regiochemistry was unambiguously assigned by 2D-NMR experiments. C-C- and C-N coupling reactions of 5-chloro or 5-oxo intermediates afforded the corresponding C-5 or N-6 substituted derivatives.
