556109-82-1

Basic information

• Product Name: C₂₈H₃₁NO₅
• Synonyms: C₂₈H₃₁NO₅
• CAS NO: 556109-82-1
• Molecular Weight: 461.558
• Mol File: 556109-82-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₃₁NO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₁NO₅(556109-82-1)
• EPA Substance Registry System: C₂₈H₃₁NO₅(556109-82-1)

Safety Data

• Hazardous Substances Data: 556109-82-1(Hazardous Substances Data)

Upstream product

• 556105-31-8 C₁₇H₂₂O₅ 
• 288399-19-9 4-(chloromethyl)-2-methylquinoline 

Downstream Products

• 556106-05-9 C₂₄H₂₃NO₅ 

Relevant articles and documents

Discovery of novel hydroxamates as highly potent tumor necrosis factor-α converting enzyme inhibitors: Part I - Discovery of two binding modes

Through a de novo design approach, hydroxamates derived from trans-cyclopropyl dicarboxylate were examined as potential TNF-α converting enzyme (TACE) inhibitors. Two distinctive series of inhibitors (A and B) were identified and shown to have different structure-activity relationship trends and selectivity profiles against other matrix metalloproteases despite their close structural similarities. X-ray crystallography of the inhibitors binding to the TACE enzyme demonstrates that each series derives its activity from the opposite enantiomer of the cyclopropyl scaffolds, which display almost superimposable hydroxamate groups that coordinate to the zinc at the catalytic site. Mode A inhibitors occupy the S1′-S3′ binding pockets, whereas mode B resides in the nonprime binding sites.