5562-22-1

Basic information

• Product Name: 3-Piperidineacetonitrile
• Synonyms: 3-Piperidineacetonitrile;3-Cyanomethylpiperidine;3-piperidinylacetonitrile
• CAS NO: 5562-22-1
• Molecular Formula: C₇H₁₂N₂
• Molecular Weight: 124.18358
• Mol File: 5562-22-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Piperidineacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidineacetonitrile(5562-22-1)
• EPA Substance Registry System: 3-Piperidineacetonitrile(5562-22-1)

Safety Data

• Hazardous Substances Data: 5562-22-1(Hazardous Substances Data)

Usage

Uses

3-Cyanomethylpiperidine is an intermediate used to prepare 2,4,6-trisubstituted pyrimidines as phosphatidylinositol 3-kinase (PI3 kinase) inhibitors and their use in treatment of cancer.

Upstream product

• 948015-72-3 tert-butyl 3-(cyanomethyl)piperidine-1-carboxylate 
• 1159982-27-0 tert-butyl 3-(cyanomethylene)piperidine-1-carboxylate 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 373356-43-5 1-Benzyloxycarbonyl-3-cyanomethylpiperidine 

Downstream Products

• 1083181-70-7 2-(1-benzylpiperidin-3-yl)ethan-1-amine 

Relevant articles and documents

Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors

A series of tryptophan-based selective nanomolar butyrylcholinesterase (BChE) inhibitors was designed and synthesized. Compounds were optimized in terms of potency, selectivity, and synthetic accessibility. The crystal structure of the inhibitor 18 in complex with BChE revealed the molecular basis for its low nanomolar inhibition (IC50 = 2.8 nM). The favourable in vitro results enabled a first-in-animal in vivo efficacy and safety trial, which demonstrated a positive impact on fear-motivated and spatial long-term memory retrieval without any concomitant adverse motor effects. Altogether, this research culminated in a handful of new lead compounds with promising potential for symptomatic treatment of patients with Alzheimer's disease.