5562-22-1

Usage

Uses

Used in Pharmaceutical Industry:
3-Piperidineacetonitrile is used as a key intermediate for the synthesis of 2,4,6-trisubstituted pyrimidines. These compounds are known as phosphatidylinositol 3-kinase (PI3 kinase) inhibitors, which play a significant role in the treatment of cancer. By targeting the PI3 kinase pathway, these inhibitors can help regulate cell growth and survival, making them valuable tools in the fight against cancer.

Upstream product

• 948015-72-3 tert-butyl 3-(cyanomethyl)piperidine-1-carboxylate 
• 1159982-27-0 tert-butyl 3-(cyanomethylene)piperidine-1-carboxylate 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 373356-43-5 1-Benzyloxycarbonyl-3-cyanomethylpiperidine 

Downstream Products

• 1083181-70-7 2-(1-benzylpiperidin-3-yl)ethan-1-amine 

Relevant academic research and scientific papers

Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors

A series of tryptophan-based selective nanomolar butyrylcholinesterase (BChE) inhibitors was designed and synthesized. Compounds were optimized in terms of potency, selectivity, and synthetic accessibility. The crystal structure of the inhibitor 18 in complex with BChE revealed the molecular basis for its low nanomolar inhibition (IC50 = 2.8 nM). The favourable in vitro results enabled a first-in-animal in vivo efficacy and safety trial, which demonstrated a positive impact on fear-motivated and spatial long-term memory retrieval without any concomitant adverse motor effects. Altogether, this research culminated in a handful of new lead compounds with promising potential for symptomatic treatment of patients with Alzheimer's disease.

Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by np y5 receptor

Compounds of formula (I): wherein: X is a group of formula (A) or (B): and R1, R2, R3, R4, n, x, y and z are as defined within are described. Processes for their preparation and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor in a warm-blooded animal, such as a human being are also described.