5564-79-4 Usage
1-Propanone, 3-phenyl-1-[2-[3-(1-piperidinyl)propoxy]phenyl]-
This is the chemical name of the compound Fendiline.
Calcium channel blocker
Fendiline is used to block the influx of calcium ions into smooth muscle cells, which results in the relaxation of blood vessels and reduced pressure in the heart.
Antiarrhythmic agent
Fendiline is used to control irregular heartbeats.
Vasodilator
Fendiline is used to improve blood flow.
Potential anti-inflammatory and cytoprotective effects
Fendiline has been studied for its potential therapeutic applications in neurological and cardiovascular diseases.
Adverse effects
Fendiline has been associated with adverse effects such as hepatotoxicity and drug interactions.
Caution advised
Fendiline should only be used under the supervision of a qualified healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 5564-79-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,6 and 4 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5564-79:
(6*5)+(5*5)+(4*6)+(3*4)+(2*7)+(1*9)=114
114 % 10 = 4
So 5564-79-4 is a valid CAS Registry Number.
5564-79-4Relevant academic research and scientific papers
Studies on propafenone-type modulators of multidrug resistance VI. Synthesis and pharmacological activity of compounds with varied spacer length between the central aromatic ring and the nitrogen atom
Chiba, Peter,Annibali, Danilo,Hitzler, Manuela,Richter, Elisabeth,Ecker, Gerhard
, p. 357 - 364 (2007/10/03)
A series of propafenone-type modulators of multidrug resistance (MDR) with varied spacer length between the central aromatic ring and the positively chargeable nitrogen atom was synthesized and tested for their ability to block P-glycoprotein-mediated transport of daunomycin out of tumor cells. Synthesis was achieved by O-alkylation of o-hydroxy-3- phenylpropiophenone with dibromoalkanes and subsequent nucleophilic substitution of the bromine with piperidine. All compounds showed high MDR- modulating activity with EC50 values from 1.450.15 μM. Generally, activity increased with increasing number of methylene groups, whereby it reaches a plateau for compounds with more than five methylene groups between the ether oxygen and the nitrogen atom.
