55643-84-0Relevant academic research and scientific papers
A reusable efficient green catalyst of 2d cu-mof for the click and knoevenagel reaction
Maity, Himadri Sekhar,Maity, Suvendu,Naskar, Kaushik,Sinha, Chittaranjan
, (2021/09/07)
[Cu(CPA)(BDC)]n (CPA = 4-(Chloro-phenyl)-pyridin-4-ylmethylene-amine; BDC = 1,4-benzenedicarboxylate) has been synthesized and structurally characterized by single crystal X-Ray diffraction measurement. The structural studies establish the copper (II) containing 2D sheet with (4,4) square grid structure. The square grid lengths are 10.775 and 10.769 ?. Thermal stability is assessed by TGA, and subsequent PXRD data establish the crystallinity. The surface morphology is evaluated by FE-SEM. The N2 adsorption?desorption analysis demonstrates the mesoporous feature (～6.95 nm) of the Cu-MOF. This porous grid serves as heterogeneous green catalyst with superficial recyclability and thermal stability and facilitates organic transformations efficiently such as, Click and Knoevenagel reactions in the aqueous methanolic medium.
Diverse C-6 substituted 4-methyl-2-(2-, 3- and 4-pyridinyl)quinolines: synthesis, in vitro anticancer evaluation and in silico studies
Kouznetsov, Vladimir V.,Robles-Castellanos, Mayra L.,Sojo, Felipe,Rojas-Ruiz, Fernando A.,Arvelo, Francisco
, p. 551 - 561 (2017/02/15)
A series of twelve 4-methyl-2-(2-, 3- and 4-pyridinyl)quinolines 7–9 was synthesized using modified Kametani reaction protocol and their in vitro cytotoxicity was tested against human cancer cell lines MCF-7, SKBR-3, PC3, HeLa, comparing with human dermis
Synthesis, molecular docking study, and cytotoxic activity of 3,4-diaryl-5-(4-pyridinyl)-1,2,4-oxadiazole
Zareian, Bita,Ghadbeighi, Sajad,Amirhamzeh, Amirali,Ostad, Seyed N.,Shafiee, Abbas,Amini, Mohsen
, p. 394 - 401 (2016/07/06)
Background: Triaryl oxadiazoles have been proven to be useful agents against various types of cancer cell lines. Nevertheless, their mechanism of action is not fully understood. Objective: Synthesis and cytotoxic activity of a new group of triaryl oxadiaz
Development of novel vitamin D receptor-coactivator inhibitors
Sidhu, Preetpal S.,Nassif, Nicholas,McCallum, Megan M.,Teske, Kelly,Feleke, Belaynesh,Yuan, Nina Y.,Nandhikonda, Premchendar,Cook, James M.,Singh, Rakesh K.,Bikle, Daniel D.,Arnold, Leggy A.
supporting information, p. 199 - 204 (2014/03/21)
Nuclear receptor coregulators are master regulators of transcription and selectively interact with the vitamin D receptor (VDR) to modulate cell differentiation, cell proliferation, and calcium homeostasis. Herein, we report the syntheses and evaluation of highly potent and selective VDR-coactivator inhibitors based on a recently identified 3-indolylmethanamine scaffold. The most active compound, PS121912, selectively inhibited VDR-mediated transcription among eight other nuclear receptors tested. PS121912 is also selectively disrupting the binding between VDR and the third nuclear receptor interaction domain of the coactivator SRC2. Genetic studies revealed that PS121912 behaves like a VDR antagonist by repressing 1,25-(OH)2D3 activated gene transcription. In addition, PS121912 induced apoptosis in HL-60.
A novel four-component synthesis of N-substituted amino acid esters
Henkel, Bernd,Weber, Lutz
, p. 1877 - 1879 (2007/10/03)
A library of N-substituted amino acid esters was synthesized using a solid phase bound organic isocyanide that provides a C1 synthon to the final molecule. This novel four-component, one-pot reaction delivers the final products in acceptable yields with high purities of the crude reaction products, facilitating the final purification. The preparation of the isocyano resin is also described the intermediates being controlled by ATR-spectroscopy.
Anil-Synthese. 22 Mitteilung. Ueber die Herstellung von Styryl und Distyryl-Derivaten des Pyridins
Siegrist, Adolf Emil,Meyer, Hans Rudolf,Gassmann, Peter,Moss, Serge
, p. 1311 - 1334 (2007/10/02)
2,4-, 2,5- and 2,6-Dimethylpyridines react with anils of aromatic aldehydes in the presence of dimethylformamide and potassium hydroxide to yield the corresponding distyrylpyridines ('anil synthesis').Under the same reaction conditions (4-methylstyryl)pyridines are converted to (stilbenylvinyl)pyridines.Similarly, the Schiff's base derived from pyridine-3-carbaldehyde and chloranile on treatment with methyl- and p-tolyl-substituted aromatic hetericycles gives the corresponding (heteroaryl-styryl)pyridines, whereas with the Schiff's bases derived from pyridine-2= and -4-carbaldehyde side reactions, such as dimerization followed by disproportionation predominate.
