5565-72-0

Basic information

• Product Name: 2-(3-nitrophenyl)-1,3,4-oxadiazole
• Synonyms: 2-(3-nitrophenyl)-1,3,4-oxadiazole;1,3,4-OXADIAZOLE, 2-(3-NITROPHENYL)-
• CAS NO: 5565-72-0
• Molecular Formula: C₈H₅N₃O₃
• Molecular Weight: 191.15
• Mol File: 5565-72-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3-nitrophenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-nitrophenyl)-1,3,4-oxadiazole(5565-72-0)
• EPA Substance Registry System: 2-(3-nitrophenyl)-1,3,4-oxadiazole(5565-72-0)

Safety Data

• Hazardous Substances Data: 5565-72-0(Hazardous Substances Data)

Usage

General Description

2-(3-nitrophenyl)-1,3,4-oxadiazole is a chemical compound with the molecular formula C8H5N3O3. It is a yellow crystalline powder that is commonly used in organic synthesis and as a building block for the preparation of various biologically active compounds and pharmaceuticals. The compound is known for its fluorescence properties, which make it useful in the development of fluorescent sensors and probes for detecting and measuring various analytes. Additionally, 2-(3-nitrophenyl)-1,3,4-oxadiazole has been studied for its potential antitumor and antimicrobial activities, making it a versatile and potentially valuable compound in pharmaceutical and chemical research.

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
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• 1895-39-2 sodium chlorodifluoroacetate 
• 645-00-1 m-iodonitrobenzene 
• 758-96-3 N,N-dimethyl-propanamide 
• 126175-90-4 3-(3-Nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.4]non-2-en-4-ylamine 
• 149-73-5 trimethyl orthoformate 
• 138267-85-3 N-[3-(3-Nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.4]non-2-en-4-yl]-formamide 
• 103274-29-9 N'-(3-nitro-benzoyl)-formohydrazonic acid ethyl ester 

Downstream Products

• 1071691-56-9 4-acetylamino-N-(4-[1,3,4]oxadiazol-2-yl-phenyl)-benzenesulfonamide 
• 92906-14-4 4-nitro-N-(4-[1,3,4]oxadiazol-2-yl-phenyl)-benzenesulfonamide 
• 92906-13-3 4-nitro-N-(3-[1,3,4]oxadiazol-2-yl-phenyl)-benzenesulfonamide 
• 92150-28-2 4-amino-N-(3-[1,3,4]oxadiazol-2-yl-phenyl)-benzenesulfonamide 
• 96432-49-4 3-sulfanilylamino-benzoic acid 
• 6336-70-5 4-(4-aminobenzenesulfonylamino)benzoic acid 
• 35219-13-7 4-(1,3,4-oxadiazol-2-yl)aniline 
• 5378-35-8 3-(1,3,4-oxadiazol-2-yl)aniline 
• 1448308-96-0 N-(3-(1,3,4-oxadiazol-2-yl)phenyl)-N-(1-(2-chlorophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-(2-methyl-1H-imidazol-1-yl)acetamide 

Relevant articles and documents

[4u202f+u202f1] Cyclization of benzohydrazide and ClCF2COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5

A facile synthesis of 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5 via [4 + 1] cyclization of ClCF2COONa with non-amine compounds containing amino groups is developed. Of note, this is the first time that halofluorinated compounds are used as C1 synthon to construct deuterated nitrogen-heterocyclic compounds. The current protocol features simple operation, readily accessible raw materials, wide substrate scope and valuable products

TiCl4 mediated facile synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope.

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.