55654-24-5

Upstream product

• 40018-26-6 1,4-dithiane-2,5-diol 
• 35276-81-4 3-oxo-3-(o-tolyl)propanenitrile 
• 118-90-1 ortho-methylbenzoic acid 
• 89-71-4 2-Methyl-benzoic acid methyl ester 

Downstream Products

• 75473-37-9 2-Acetylamino-N-[3-(2-methyl-benzoyl)-thiophen-2-yl]-acetamide 
• 75473-53-9 7-Chloro-1-methyl-5-o-tolyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 75473-41-5 7-Chloro-5-o-tolyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 75473-21-1 2-Iodo-N-[3-(2-methyl-benzoyl)-thiophen-2-yl]-acetamide 
• 75473-26-6 2-Amino-N-[3-(2-methyl-benzoyl)-thiophen-2-yl]-acetamide 
• 75473-31-3 5-o-Tolyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 55865-75-3 1-methyl-5-o-tolyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 75473-16-4 2-Chloro-N-[3-(2-methyl-benzoyl)-thiophen-2-yl]-acetamide 

Relevant academic research and scientific papers

An efficient synthesis of 2-aminothiophenes via the gewald reaction catalyzed by an N-methylpiperazine-functionalized polyacrylonitrile fiber

A new N-methylpiperazine-functionalized polyacrylonitrile fiber has been developed to catalyze the Gewald reaction between 2,5-dihydroxy-1,4-dithiane and activated nitriles to afford 3-substituted 2-aminothiophenes in good to excellent yields (65-91%). Low catalyst loading (8.0 mol%), simple procedure, high yields, excellent recyclability, and reusability (up to 10 times with minimal loss of catalytic activity) are attractive features of this fiber catalyst. Georg Thieme Verlag Stuttgart · New York.