55659-50-2Relevant academic research and scientific papers
Enzymatic desymmetrization of 2,5-dideoxystreptamine precursors
Chenevert, Robert,Jacques, Frederic
, p. 1017 - 1021 (2007/10/03)
The stereoselective enzymatic acylation of meso-6,7-diazabicyclo[3.2.1]oct-6-ene-2,4-diol 4 and meso-4,6-diazidocyclohexane-1,3-diol 5 in organic media gave the corresponding monoesters in high enantiomeric excess. The hydrolysis of the corresponding diac
Total synthesis of 2,5-dideoxystreptamines
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, (2008/06/13)
The dextrorotatory and levorotatory isomers of 1,6-Carbamate-3N-carbethoxy-2,5-dideoxystreptamine (I) have been found to be very valuable intermediates useful in the preparation of totally synthetic aminoglycoside antibiotics. An example of such an aminoglycoside antibiotic is 5-deoxykanamycin A.
Process for the preparation of 2,5-dideoxystreptamine and of a novel intermediate therefor
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, (2008/06/13)
The aminocyclitol 2,5-dideoxystreptamine may be prepared by a novel two-step synthesis from cis-4,8-dioxatricyclo [5.1.0.03,5 ]octane. The aminocyclitol and a novel intermediate in the synthesis thereof are utilized by a Micromonospora inyoensis (M. inoyensis strain 155OF-1G NRRL 5742) for the elaboration of a novel antibacterial agent designated Mutamicin 2.
Synthesis of cis-1,4-cyclohexadiene dioxide
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, (2008/06/13)
Cis-1,4-cyclohexadiene dioxide is a valuable intermediate useful in the preparation of totally synthetic aminoglycosides. An example of such an aminoglycoside is 5-deoxykanamycin A.
2,5-Dideoxystreptamine and the production thereof
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, (2008/06/13)
2,5-Dideoxystreptamine is provided which is a new compound useful in the fermentative production of 5-deoxyneamine having useful antibacterial activity by culturing a microorganism. The production of 2,5-dideoxystreptamine is made by catalytic hydrogenation of 6,7-diaza-bicyclo[3.2.1]octane-2,4-diol which is also a new compound.
