55659-75-1

Usage

Uses

Used in Pharmaceutical Industry:
Deltonin is used as a potential therapeutic agent for the prevention and treatment of chronic diseases such as cancer, cardiovascular disease, and neurodegenerative disorders. Its antioxidant and anti-inflammatory properties contribute to its potential health benefits, making it a promising candidate for further research and development.
Used in Nutraceutical Industry:
Deltonin can be used as a dietary supplement or functional food ingredient due to its potential health-promoting effects. Its antioxidant and anti-inflammatory properties may help support overall health and well-being, and reduce the risk of chronic diseases.
Used in Cosmetic Industry:
Deltonin's antioxidant properties can be utilized in cosmetic products to protect the skin from oxidative stress and environmental damage. It may also have potential anti-aging and skin health benefits due to its ability to reduce inflammation and promote skin health.
Used in Agricultural Industry:
Deltonin's antioxidant properties can be applied in agriculture to improve the shelf life and quality of fruits and vegetables. It may also have potential applications in plant protection, as its antioxidant properties could help protect plants from oxidative stress caused by environmental factors.

Upstream product

• 94992-07-1 (25R)-O-β-D-glucopyranosyl-22-O-methylfurost-5-ene-3β,22ξ,26-triol 3-O-2)-O-<β-D-glucopyranosyl-(1->4)>-β-D-glucopyranoside> 
• 1240293-61-1 (25R)-26-[(β-D-glucopyranosyl)oxy]-22α-hydroxyfurost-5-en-3β-yl O-β-D-glucopyranosyl-(1→4)-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside 

Downstream Products

• 19057-67-1 ophiopogonin C 
• 14144-06-0 trillin 
• 512-04-9 diosgenin 
• 55639-73-1 (25R)-5-en-spirostane-3β-ol 3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside 

Relevant academic research and scientific papers

Steroidal Glycosides from the Aerial Parts of Avena sativa L. And Their Cytotoxic Activity

Twelve steroidal glycosides (1-12) were isolated from the aerial parts of Avena sativa L. (Poaceae). Among the isolated compounds, 1 was directly isolated from the plant for the first time, and 2-6 were new steroidal glycosides. The structures of 1-6 were determined by analysis of their spectroscopic data, chemical transformations, and chromatographic and spectroscopic analyses of the hydrolyzed products. Compounds 5 and 6 were novel steroidal glycosides with a B-ring contracted skeleton (B-nor steroid). Compounds 1, 9, 11, and 12 were cytotoxic to HL-60 human promyelocytic leukemia cells, MIA PaCa-2 human pancreatic carcinoma cells, and A549 human lung adenocarcinoma cells with IC50 values ranging from 0.79 to 13.5 μM. HL-60 cells treated with 1 exhibited apoptotic characteristics, namely, condensed nuclear chromatin, accumulation of sub-G1 cells, and activation of caspase-3. Additionally, the loss of the mitochondrial membrane potential and the release of cytochrome c into the cytoplasm in 1-treated HL-60 cells suggested that 1 induced apoptosis through a mitochondrial-dependent apoptotic pathway.

Pathways of biotransformation of zingiberen newsaponin from Dioscorea zingiberensis C. H. Wright to diosgenin

A new steroidal saponin-β-glucosidase from Aspergillus flavus that specifically hydrolyzed the terminal β-d-glucosyl group at the C-3 position of zingiberen newsaponin, deltonin and trillin from Dioscorea zingiberensis C. H. Wright (DZW) was purified, and characterized. The optimal temperature and pH for the new steroidal saponin-β-glucosidase was 50 C and pH 5.0. The steroidal saponin-β-glucosidase was stable at 30-60 C, and retained more than 80% activity. Further, the purified protein was analyzed by ESI-Q-TOF proteomic analyzer. The results indicated that this enzyme is a β-glucosidase of the type glycosidase hydrolase 3 (GH3). Using a combination of the steroidal saponin-β-glucosidase and steroidal saponin-α-1,2-rhamnosidase from Curvularia lunata obtained previously in our lab, the saponins zingieren newsaponin and deltonin could be converted to diosgenin. The pathways of converting zingiberen newsaponin and deltonin into diosgenin by the two key enzymes were elucidated in this study.

Studies on the Constituents of Palmae Plants. II. The Constituents of Rhapis exelsa Henry and R. humilis Bl.

Further studies have been done on the constituents of the stems, underground parts and leaves of two Palmae plants, Rhapis exelsa Henry and R. humilis Bl.We isolated and identified dioscin, Pb, deltonin, methyl proto-dioscin, methyl proto-Pb and methyl proto-deltonin from the stems, dioscin, methyl proto-dioscin and methyl proto-Pb from the underground parts, and saponaretin (= isovitexin), methyl proto-dioscin, methyl proto-Pb and methyl proto-rhapissaponin from the leaves of R. exelsa.On the other hand we isolated and identified prosapogenin A of dioscin, dioscin, deltonin, methyl proto-prosapogenin A of dioscin, methyl proto-dioscin and methyl proto-deltonin from the stems, dioscin, methyl proto-prosapogenin A of dioscin, methyl proto-dioscin and methyl proto-Pb from the underground parts, and saponaretin, vitexin, isoorientin, methyl proto-prosapogenin A of dioscin, methyl proto-dioscin and methyl proto-Pb from the leaves of R. humilis.Methyl proto-rhapissaponin is a new furostanol saponin and its structure has been established to be 26-O-β-D-glucopyranosyl 22-O-methyl-25(R)-furost-5-en-3β,22,26-triol 3-O-4)-α-L-rhamnopyranosyl(1->4)-α-L-rhamnopyranosyl(1->4)>-2)>-β-D-glucopyranoside.This is the second report of the isolation of steroidal saponins from Palmae plants, and the results are interesting from the standpoint of chemotaxonomy. Keywords - Rhapis exelsa; Rhapis humilis; Palmae; steroidal saponin; furostanol oligoside; diosgenin; flavone glycoside; flavone C-glycoside; methyl proto-rhapissaponin