55662-06-1

Usage

Chemical structure

Contains a chloropyrimidine group attached to an ethanolamine derivative.

Usage

Commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Potential applications

Building block for the preparation of various biologically active compounds.

Other uses

Production of dyes and pigments.

Versatility

Compound's functional groups make it suitable for various chemical reactions and applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C6H8ClN3O/c7-6-9-2-1-5(10-6)8-3-4-11/h1-2,11H,3-4H2,(H,8,9,10)

Upstream product

• 1224600-39-8 2-chloro-N-(2-methoxyethyl)pyrimidin-4-amine 
• 3934-20-1 2,6-Dichloropyrimidine 
• 141-43-5 ethanolamine 

Downstream Products

• 1034358-34-3 (2R,3R)-3-(5-bromo-2-{4-[4-(2-hydroxyethylamino)pyrimidin-2-ylamino]-phenylamino}pyrimidin-4-yloxy)butan-2-ol 
• 1034358-32-1 (2R,3R)-3-(5-bromo-2-{4-[4-(2-hydroxyethylamino)pyrimidin-2-ylamino]-phenylamino}pyrimidin-4-ylamino)butan-2-ol 
• 671225-39-1 cardiogenol C 

Relevant academic research and scientific papers

Small Molecules that Induce Cardiomyogenesis in Embryonic Stem Cells

A phenotypic cell-based screen of a large combinatorial chemical library led to the identification of a class of diaminopyrimidine compounds (cardiogenol A-D) which can selectively and efficiently induce mouse embryonic stem cells (ESCs) to differentiate into cardiomyocytes. ESC-derived cardiomyocytes were shown to express multiple cardiac muscle markers, including myosin heavy chain, GATA-4, MEF2, and Nkx2.5, and spontaneously form beating regions. Such small molecules will serve as useful chemical probes to study cardiac muscle differentiation and may ultimately facilitate the therapeutic application of ESCs for cardiac repair. Copyright

Pyrimidine derivatives as anti-diabetic agents

The pyrimidine derivatives as anti-diabetic agents are chloropyrimidinyl derivatives having the general formula of compound 81, wherein R1 is —N(CH3)CH2CH2OH (compound 81c) or —N(H)CH2CH2OH (compound 81f) or the general formula of compound 82, wherein R2 is —N(CH3)CH2CH2OH (compound 82c) or —N(CH2CH2)2O (compound 82d), as follows: The derivatives may be used for treating diabetes in humans or animals and have demonstrated efficacy, specifically in treating type 2 diabetes. Two methods of synthesizing the pyrimidine derivatives are described herein. The method using microwaves (Method B) is a green method that can provide high yields in a short time and with high purity. The compounds act as GLP-1 receptor agonists and are more potent than conventional drugs. As such, the compounds may be used in lower doses, and, hence, have fewer side effects.

Antibacterial Compounds

The present invention provides a compound of the following formula, salts, racemates, diastereomers, enantiomers, esters, carbamates, phosphates, sulfates, deuterated forms and prodrugs thereof. Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.

MODULATORS FOR AMYLOID BETA

The invention relates to compounds of formula wherein the substituents are as described in claim 1. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposi

NOVEL HETARYL-PHENYLENEDIAMINE-PYRIMIDINES AS PROTEIN KINASE INHIBITORS

The invention relates to novel hetaryl-phenylenediamine-pyrimidines and to their structurally related oxygen and sulphur analogues of the general formula I, processes for their preparation, and their use as medicaments.

2, 4 - DIAMINOPYRIMIDINES AND THEIR USE FOR INDUCING CARDIOMYOGENESIS

The present invention provides compounds of formula (I) useful for inducing cardiomyogenesis in mammalian cells, particularly embryonic stem cells, in vitro and in vivo.