556795-90-5

Upstream product

• 83067-20-3 5-(tert-butyldimethyl-silyloxy)pentan-1-ol 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 550343-27-6 methyl 2-azido-3-{4-[5-(tert-butyldimethylsilyloxy)pentyloxy]phenyl}propenoate 
• 502937-01-1 N-{(2S)-1-[2-(tert-butyloxycarbonyl)adamantyl-2-amino]-3-(4-tert-butyloxyphenyl)-1-oxo-propan-2-yl} 1-{6-[N,N'-bis(tert-butyloxycarbonyl)guanidino]hexyl}-6-{[5-N,N'-bis(tert-butyloxycarbonyl)guanidino]pentyloxy}indole-2-carboxamide 

Relevant academic research and scientific papers

Synthesis and biological studies of novel neurotensin(8-13) mimetics

Novel neurotensin (NT) (8-13) (Arg8-Arg9-Pro10-Tyr11-Ile 12-Leu13) mimetics 3, 4 were designed by adopting all intrinsic functional groups of the native neurotensin(8-13) and using a substituted indole as a template to mimic the pharmacophore of NT(8-13). Biological studies at subtype 1 of the NT receptor showed that 3 has a 55 and 580 nM binding affinity at rat and human neurotensin receptors, respectively. As a comparison, compounds 5 and 6 were also synthesized. The binding difference between 3, 4 and 5, 6 argues the importance of the carboxylic group in achieving higher potency NT(8-13) mimetics.