5568-42-3

Upstream product

• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 555-16-8 4-nitrobenzaldehdye 
• 61-82-5 4H-1,2,4-triazol-3-amine 
• 61-82-5 3-amino-1,2,4-triazole 

Downstream Products

• 1481718-26-6 C₁₀H₉N₅O₄S 

Relevant academic research and scientific papers

RETRACTED ARTICLE: A facile sonochemical protocol for synthesis of 3-amino- And 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents

A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3-5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, 1HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) strains.

Antiglycation activity of triazole schiff’s bases against fructose-mediated glycation: In vitro and in silico study

Background: Advanced glycation end products (AGEs) are known to be involved in the pathophysiology of diabetic complications, neurodegenerative diseases, and aging. Preventing the formation of AGEs can be helpful in the management of these diseases. Objec

Structure investigations of Schiff bases derived from 3-amino-1H-1,2,4-triazole

In the present paper, twelve Schiff bases derived from 3-amino-1H-1,2,4-triazole (ATz) and various benzaldehydes, and salicylaldehydes were synthesized. The 1H, 13C, and 15N NMR data are discussed in relation to the structure of ATz and its imine products. In addition, X-ray, ATR-FTIR, and UV–Vis analytical techniques are used for structure elucidation of ATz-based Schiff bases. It was found that the starting material, 3-amino-1H-1,2,4-triazole, exists as tautomeric mixture of three forms (Graphical Abstract) in solution, whereas in the solid state (13C and 15N CPMAS data) potentially tautomeric proton is located on nitrogen atom traditionally marked as N-2 (Graphical Abstract, 2N–H structure). All investigated Schiff bases derived from salicylaldehydes exist in both phases as tautomeric equilibrium mixtures, where enol-imine forms are dominated structures. The positions of those equilibria only very slightly depend on substituents in phenol ring. Generally, the contributions of keto-amine forms in the solid state are higher comparing with DMSO solutions.

Synthesis, β-Glucuronidase Inhibition, and Molecular Docking Studies of 1,2,4-Triazole Hydrazones

A series of 1,2,4-triazole hydrazones 1–25 has been synthesized and characterized using different spectroscopic techniques including FT-IR, 1H-NMR, and ESI MS spectrometry. The synthetic derivatives were evaluated for their β-glucuronidase enzy

Synthesis of triazole Schiff bases: Novel inhibitors of nucleotide pyrophosphatase/phosphodiesterase-1

A series of Schiff base triazoles 1-25 was synthesized and evaluated for their nucleotide pyrophosphatase/phosphodiesterase-1 inhibitory activities. Among twenty-five compounds, three compounds 10 (IC50 = 132.20 ± 2.89 μM), 13 (IC50

[4+2] Cycloaddition reaction: Synthesis and antifungal activities of 2-substituted 1,2,4-triazolo[3,2-c][1,3,5]thiadiazine-3,3-dioxides

3-Benzylidineamino-1,2,4-triazole undergoes [4+2] cycloaddition reaction with sulfene resulting in good yield of [1,2,4]-triazolo[3,2-c][1,3,5]- thiadiazine-3,3-dioxide derivatives. The title compounds have been screened for their antifungal activities.

1H NMR, 13C NMR and mass spectral studies of some Schiff bases derived from 3-amino-1,2,4-triazole

Heterocyclic Schiff bases derived from 3-amino-1,2,4-triazole and different substituted aromatic aldehydes are prepared and subjected to 1H NMR, 13C NMR and mass spectral analyses. 1H NMR spectra in DMSO exhibit a sharp si

Spectroscopic and Conductometric Studies on some Schiff Bases

The electronic absorption spectra of some Schiff bases derived from 3-amino-1,2,4-triazole have been investigated in organic solvents of different polarities.Assignment of the absorption bands, solvent effects, and spectral structure correlations are cons