556801-47-9

Basic information

• Product Name: 1-(2-fluoro-4-nitrophenyl)-4-(4-methoxyphenyl)piperazine
• Synonyms: 1-(2-fluoro-4-nitrophenyl)-4-(4-methoxyphenyl)piperazine
• CAS NO: 556801-47-9
• Molecular Weight: 331.347
• Mol File: 556801-47-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2-fluoro-4-nitrophenyl)-4-(4-methoxyphenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-fluoro-4-nitrophenyl)-4-(4-methoxyphenyl)piperazine(556801-47-9)
• EPA Substance Registry System: 1-(2-fluoro-4-nitrophenyl)-4-(4-methoxyphenyl)piperazine(556801-47-9)

Safety Data

• Hazardous Substances Data: 556801-47-9(Hazardous Substances Data)

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 154590-33-7 1-(2-fluoro-4-nitrophenyl)piperazine 
• 38212-30-5 4-(4-methoxyphenyl)piperazine 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 1427177-61-4 4-(3-fluoro-4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one 
• 1427177-62-5 1-(sec-butyl)-4-(3-fluoro-4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one 
• 1427177-63-6 1-(sec-butyl)-4-(3-fluoro-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one 
• 1427177-50-1 4-(4-(4-(4-(((2S,4R)-2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)-3-fluorophenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1427177-60-3 N-(3-fluoro-4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)hydrazinecarboxamide 
• 1427177-59-0 phenyl (3-fluoro-4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)carbamate 
• 556801-49-1 {3-fluoro-4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-carbamic acid benzyl ester 
• 465520-05-2 (R)-3-{3-Fluoro-4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-5-hydroxymethyl-oxazolidin-2-one 
• 556801-48-0 3-fluoro-4-(4-(4-methoxyphenyl)piperazin-1-yl)aniline 

Relevant articles and documents

Benzofuroxan Derivatives as Potent Agents against Multidrug-Resistant Mycobacterium tuberculosis

Tuberculosis (TB) is currently the leading cause of death related to infectious diseases worldwide, as reported by the World Health Organization. Moreover, the increasing number of multidrug-resistant tuberculosis (MDR-TB) cases has alarmed health agencies, warranting extensive efforts to discover novel drugs that are effective and also safe. In this study, 23 new compounds were synthesized and evaluated in vitro against the drug-resistant strains of M. tuberculosis. The compound 6-((3-fluoro-4-thiomorpholinophenyl)carbamoyl)benzo[c][1,2,5]oxadiazole 1-N-oxide (5 b) was particularly remarkable in this regard as it demonstrated MIC90 values below 0.28 μM against all the MDR strains evaluated, thus suggesting that this compound might have a different mechanism of action. Benzofuroxans are an attractive new class of anti-TB agents, exemplified by compound 5 b, with excellent potency against the replicating and drug-resistant strains of M. tuberculosis.

ITRACONAZOLE ANALOGS AND USE THEREOF

Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.