55682-24-1Relevant articles and documents
A sequential one-pot approach to 1,2,4,5-tetrasubstituted-2H-imidazole synthesis from disubstituted alkynes
Boominathan, Siva Senthil Kumar,Chen, Chung-Yu,Huang, Po-Jui,Hou, Ruei-Jhih,Wang, Jeh-Jeng
, p. 6914 - 6918 (2015)
A sequential one-pot approach to the tetrasubstituted 2H-imidazole scaffolds has been developed from disubstituted alkynes and structurally diverse ketones. The reaction proceeds via a diketo intermediate generated from internal alkynes followed by the addition of ammonium acetate and a suitable ketone, affording a diverse range of 2H-imidazoles. Using air-moisture stable reaction conditions and inexpensive reagents, the transformation demonstrates a broad substrate scope and good functional group compatibility.