55686-04-9Relevant academic research and scientific papers
α-Amino Acids as Nucleophilic Acyl Equivalents, IV. Synthesis of Symmetrical Ketones by Means of 2-Phenyl-2-oxazolin-5-one
Lohmar, Rainald,Steglich, Wolfgang
, p. 3706 - 3715 (2007/10/02)
2-Phenyl-2-oxazolin-5-one (2), itself easily derivable from hippuric acid (1), on reaction with allyl, benzyl or phenacyl halides undergoes 4,4-disubstitution, if the reaction is conducted in dipolar aprotic solvents in presence of weak bases.Hydrolysis of the resulting oxazolinones 3 leads to α,α-dialkylaed hippuric acids 4, which may be oxidized to symmetrical ketones 5 by means of lead tetraacetate.
