55701-92-3Relevant academic research and scientific papers
Kinetic resolution in the [2+2] cycloaddition of ketenes: An experimental and theoretical study
Rullire, Pauline,Carret, Sbastien,Milet, Anne,Poisson, Jean-Franois
, p. 3876 - 3881 (2015)
The kinetic resolution of Z and E olefins by [2+2] cycloaddition with ketenes allows the isolation of pure E olefin, as well as the synthesis of pure cis-cyclobutanones, starting from Z/E mixtures. A computational rationale for this kinetic difference is reported. The obtained difference of energy of activation matches with the experimental results.
CYCLOBUTANONES FOR THE STEREOSELECTIVE SYNTHESIS OF BIFUNCTIONAL MACROLIDE INTERMEDIATES
Frater, G.,Mueller, U.,Guenther, W.
, p. 1133 - 1136 (2007/10/02)
Beckmann fragmentation of the oximes 5 and 6 respectively, which were derived from the cyclobutanones 3 and 4, furnished the bifunctional five carbon units 7 and 8 with ca. 98percent and 91percent stereoselectivity.
