55703-68-9Relevant academic research and scientific papers
A phenol derivative and its application
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Paragraph 0125; 0126-0127, (2017/02/28)
A phenol derivative and a use thereof are disclosed. The phenol derivative comprises a compound as represented by structural formulas (I), (II) or (III) or a pharmaceutically acceptable salt, ester and amide thereof. In structural formulas (I), (II) or (III), R1 is selected from an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an aryl group, an aralkyl group, halogen or an acyl group; R2 and R3 are each independently selected from hydrogen, an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group or an acyl group; and R4, R5, R6 and R7 are each independently selected from hydrogen, an alkyl group, a cycloalkyl group, an aryl group or an aralkyl group. Also disclosed is the use of the compound or the pharmaceutically acceptable salt, ester and amide thereof in the preparation of drugs used for treating immune disease, inflammation or autoimmune disease.
SUBSTITUTED AMIDE COMPOUND
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Page/Page column 27, (2012/07/28)
A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula: In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or —(CRX1RX2)n—; n is 1, 2, 3, or 4; RX1 and RX2 are hydrogen, etc.; Y1 to Y5 are each CRY or N; each RY is hydrogen, etc.; R1 and R2 are hydrogen, etc.; m is 1, 2, or 3; R3 is hydrogen, etc.; and R4 is an optionally substituted lower alkyl, etc.
