557084-20-5

Downstream Products

• 557084-22-7 4,5-bis-p-tolylsulfanyl-3H-thiazol-2-one 
• 557084-24-9 3-methyl-4-(toluene-4-sulfonyl)-5-p-tolylsulfanyl-3H-thiazol-2-one 
• 557084-31-8 3-methyl-4,5-bis-p-tolylsulfanyl-3H-thiazol-2-one 
• 557084-21-6 3-methyl-4-tosyl-5-chloro-1,3-thiazol-2(3H)-one 

Relevant academic research and scientific papers

Cyclocondensation of 1-tosyl-2,2-dichloroethenyl isothiocyanate with O-, S-, N-, and C-nucleophiles

Treatment of 1-tosyl-2,2-dichloroethenyl isothiocyanate with alcohols, thiols, primary and secondary amines, hydrazine and its derivatives, and phosphonium ylides results in addition of the O-, S-, N-, or C-nucleophilic center to the isothiocyanate group, followed by cyclocondensation with elimination of hydrogen chloride and formation of the corresponding 2-functionally substituted 4-tosyl-5-chloro-1,3-thiazoles. Further transformations of these compounds were studied, and a series of previously unknown types of 3-functionally substituted 1,3-thiazole derivatives were prepared.