55717-40-3

Basic information

• Product Name: 2-Bromo-5-hydroxypyridine
• Synonyms: 6-Bromopyridin-3-ol;2-Bromo-5-hydroxypyridine;2-BroMo-5-hydroxypyr;2-Bromo-5-hydroxypyridine radical ion(1+);2-BROMO-5-HYDROXYPYRIDINE(RS20006810)
• CAS NO: 55717-40-3
• Molecular Formula: C5H4BrNO
• Molecular Weight: 174
• EINECS: -0
• Mol File: 55717-40-3.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 373 °C at 760 mmHg
• Flash Point: 179.4 °C
• Appearance: /
• Density: 1.789 g/cm³
• Vapor Pressure: 4.3E-06mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 2-Bromo-5-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-hydroxypyridine(55717-40-3)
• EPA Substance Registry System: 2-Bromo-5-hydroxypyridine(55717-40-3)

Safety Data

• Hazardous Substances Data: 55717-40-3(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-hydroxypyridine is a chemical compound with the molecular formula C5H4BrNO. It is a pyridine derivative that contains a bromine atom and a hydroxyl group attached to the pyridine ring. 2-Bromo-5-hydroxypyridine is commonly used as an intermediate in organic synthesis for the preparation of pharmaceuticals and agrochemicals. It is also used as a building block for the synthesis of various heterocyclic compounds. The compound is known for its mild but selective reactivity, making it a valuable reagent in the field of organic chemistry. Additionally, 2-Bromo-5-hydroxypyridine has been studied for its potential biological and pharmacological activities.

InChI:InChI=1/C5H4BrNO/c6-5-2-1-4(8)3-7-5/h1-3,8H

Upstream product

• 4487-59-6 2-bromo-5-nitropyridine 
• 13534-97-9 6-bromopyridine-3-amine 
• 186593-28-2 5-acetoxy-2-bromopyridine 
• 624-28-2 2,5-dibromopyridine 
• 42834-01-5 2-bromo-5-ethoxy-pyridine 
• 214360-62-0 2-[(6-bromo)pyridin-3-yl]-4,4',5,5'-tetramethyl-1,3-dioxaborolane 
• 223463-14-7 6-bromopyridin-3-ylboronic acid 

Downstream Products

• 1620685-11-1 C₂₂H₂₉N₃O₃ 
• 1624604-28-9 (4S,6S)-4-(5-((5-cyclobutoxypyridin-2-yl)ethynyl)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 1624604-27-8 (4S,6S)-4-(5-((5-(difluoromethoxy)pyridin-2-yl)ethynyl)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 1432129-23-1 C₁₄H₁₅NOS 
• 1620691-18-0 2-bromo-5-(3,3,3-trifluoro-propoxy)-pyridine 
• 1144110-15-5 2-bromo-5-propoxy-pyridine 
• 1593701-07-5 methyl 2-(5-(4-methoxybenzyloxy)pyridin-2-yl)thiazole-5-carboxylate 
• 1381947-85-8 2-bromo-5-(4-methoxybenzyloxy)pyridine 
• 68692-50-2 2-tert-butyl-5-hydroxypyridine 
• 1114235-30-1 2-bromo-4-formyl-5-tosyloxypyridine 
• 857992-23-5 2-bromo-5-isopropoxypyridine 
• 713526-59-1 6-(8-hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridin-3-ol 
• 857429-81-3 4,6-dibromo-pyridin-3-ol 

Relevant articles and documents

Highly efficient heterogeneous V2O5@TiO2 catalyzed the rapid transformation of boronic acids to phenols

A V2O5@TiO2 catalyzed green and efficient protocol for the hydroxylation of boronic acid into phenol has been developed utilizing environmentally benign oxidant hydrogen peroxide. A wide range of electron-donating and the electron-withdrawing group-containing (hetero)aryl boronic acids were transformed into their corresponding phenol. The methodology was also applied successfully to transform various natural and bioactive molecules like tocopherol, amino acids, cinchonidine, vasicinone, menthol, and pharmaceuticals such as ciprofloxacin, ibuprofen, and paracetamol. The other feature of the methodology includes gram-scale synthetic applicability, recyclability, and short reaction time.

4-((6-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL)PYRIDIN-3-YL)OXY)BENZONITRILE AND PROCESSES OF PREPARATION

Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1- difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile.

Synthesis of 9,9′-Spirobifluorenes and 4,5-Diaza-9,9′-spirobifluorenes and Their Application as Affinity Materials for Quartz Crystal Microbalances

Two different classes of aza analogues of 9,9′-spirobifluorenes have been synthesized. These were obtained by either furnishing the spirobifluorene with additional pyridyl moieties or by installing the aza function directly into the spirobifluorene core. These structurally rigid compounds were then evaluated as affinity materials for quartz crystal microbalances and proved to be highly potent for the detection of volatile organic compounds.