55725-95-6Relevant academic research and scientific papers
Glucosylhydrazines,6. - Synthesis of Pyrazole, Pyrazolopyrimidine, and 1H-1,2,4-Triazole Gluconucleosides from Glucose Hydrazones
Schmidt, Richard R.,Guilliard, Wolfgang,Heermann, Dieter
, p. 2309 - 2317 (2007/10/02)
The β-linked pyrazole gluconucleosides 6b, 12b, 13b, and 14b were obtained regio- and diastereoselectively from 2,3,4,6-tetra-O-benzyl-D-glucose hydrazone (5b) and acetylacetone, (ethoxymethylene)malondinitrile, (ethoxymethylene)cyanoacetate, and (aminomethylene)cyanoacetamide, respectively, in a one-pot reaction after two ring closures. 12b and 13b were transformed into the unprotected pyrazolopyrimidine gluconucleosides 15a and 16a (analogues of adenosine and inosine).Similarly from 5b and N-(ethoxymethylene)oxalate monoamide the β-linked glucopyranosyl-1H-1,2,4-triazole-5-carboxylate 20 and from 5b and activated formic acid derivatives the parent triazole derivative 22 were obtained.
Derivatives of hydrazino-monosaccharides and aldohexoses which are useful as intermediates for preparing compounds or as compounds which lower the uric acid
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, (2008/06/13)
Substituted hydrazino- and pyrazolo-aldopentoses and aldohexoses, which are useful as intermediates for preparing compounds, as compounds which lower the uric acid level in the blood, and as bactericides, are provided. The substituted hydrazino compounds also enter into chemical reactions which are not possible with their unsubstituted counterparts.
