5573-22-8Relevant academic research and scientific papers
Synthesis and biological activities of substituted glycyrrhetic acids
Baran,Langford,Liang,Pitzele
, p. 184 - 191 (2007/10/15)
18β Glycyrrhetic acid (I) was converted in good yield to a 3 oxo 4,4 bis (nor 18β olean 4 ene) derivative in 25% overall yield. Derivatives of I substituted in the A, B, C, and E rings were also prepared. Several 11 deoxoglycyrrhetic acid derivatives exhibited desoxycortone antagonism. In particular, when administered subcutaneously, 3 oxo 18β olean 12 en 30 oic acid had about 75% the activity of spironolactone administered subcutaneously. Several compounds also exhibited weak antiviral and antiinflammatory properties.
