5574-97-0

Usage

Uses

Used in Pharmaceutical Industry:
Tetrabutylammonium phosphate is used as an anti-HIV-active nucleoside triphosphate prodrug, playing a crucial role in the development of treatments for HIV/AIDS.
Used in Analytical Chemistry:
Tetrabutylammonium phosphate monobasic serves as a suitable reagent for the resolution of disaccharides through reverse-phase ion-pairing high-performance liquid chromatography (RPIP-HPLC). It is also used for the disaccharide analysis of 35S-heparan sulfate (HS) and as a folding buffer for the dissolution of desalted oligonucleotides.
Used in Research:
Tetrabutylammonium phosphate is utilized in the analysis of tetrasaccharides and 35S-disaccharides by HPLC, as well as in the preparation of monobasic tetrabutylammonium phosphate (TBAP) imprinted polymers, which are useful for selective recognition and separation of target molecules.
Used in Supramolecular Chemistry:
TBAP acts as an anion to probe the structure, stability, and intramolecular flexibility of a series of azacrown ethers, contributing to the understanding of host-guest interactions and the development of new supramolecular systems.

InChI:InChI=1/C16H36N.H3O4P/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;1-5(2,3)4/h5-16H2,1-4H3;(H3,1,2,3,4)/q+1;/p-3

Upstream product

• 2052-49-5 tetra(n-butyl)ammonium hydroxide 
• 1186217-06-0 C₁₆H₃₆N⁽¹⁺⁾*C₇₂H₇₂N₄O₉*H₂O₄P^(1-) 
• 1186217-07-1 C₁₆H₃₆N⁽¹⁺⁾*C₃₆H₄₈N₄O₉*H₂O₄P^(1-) 

Downstream Products

• 857447-79-1 tetrabutylammonium pyrophosphate 
• 462125-27-5 Pt(PPh3)2[η3-CH2C(OPO3H)CH2] 
• 1186217-06-0 C₁₆H₃₆N⁽¹⁺⁾*C₇₂H₇₂N₄O₉*H₂O₄P^(1-) 
• 1186217-07-1 C₁₆H₃₆N⁽¹⁺⁾*C₃₆H₄₈N₄O₉*H₂O₄P^(1-) 

Relevant academic research and scientific papers

Palladium-catalyzed heck reaction of aryl chlorides under mild conditions promoted by organic ionic bases

An efficient Pd-catalyzed Heck reaction of aryl chlorides with olefins under mild conditions is described. High yields of products were achieved with n-Bu4N+OAc- as base. Significantly, the temperature of the Heck reaction of diverse nonactivated aryl chlorides can be lowered to 80 °C. The new reaction system can also tolerate a wider range of olefins.

Encapsulated binding sites - Synthetically simple receptors for the binding and transport of HCl

We report a receptor with an encapsulated amine/amide binding site, which binds HCl with high affinity in organic media - the rate of HCl transport through an apolar phase is controlled by the degree of encapsulation of the HCl binding site.

Effect of spacer geometry on oxoanion binding by bis- and tetrakis-thiourea hosts

Hosts with thiourea groups bind anions by formation of multiple hydrogen bonds. This contribution discusses how spacers linking two or four thiourea groups affect the host affinity and selectivity. While most of the bis-thioureas bind H2PO4- preferentially, the extent of selectivity over chloride, acetate, and H2AsO4- is determined by the size of the binding cavity. A tetrakis-thiourea is shown to exhibit a unique H2AsO4- selectivity, and the discrimination of chloride is enhanced by specific solvation in dimethyl sulfoxide.

Kinetics and mechanism of phosphate-catalyzed hydrolysis of benzoate esters: Comparison with nucleophilic catalysis by imidazole and o-iodosobenzoate

Phosphate-catalyzed hydrolysis of 2,4-dinitrophenyl 4-X-benzoate, and 3- or 4-Y-phenyl 3,5-dinitrobenzoates, where X and Y are substituents, has been studied spectrophotometrically. The following conclusions are based on catalytic rate constants, solvent

A novel phosphate chemosensor utilizing anion-induced fluorescence change

(figure presented) The neutral receptor N,N′-bis{3,5-di[(1-pyrenylmethyl)carbamoyl]benzyl} pyridine-2,6-dicarbamide (2) provides a pseudo-tetrahedron cleft and multiple hydrogen bondings to form a 1:1 complex with phosphate ion in a highly selective manne

An azophenol-based chromogenic anion sensor

(equation presented) A new chromogenic azophenol-thiourea based anion sensor, 2, has been developed. This system allows for the selective colorimetric detection of F-, H2PO4-, and AcO-. Selectivity trends turned out to be dependent upon guest basicity and conformational complementarity between 2 and the guest.

UNE METHODE SIMPLE DE SYNTHESE DES PHOSPHATES TERPENIQUES ALLYLIQUES PRIMAIRES ET TERTIAIRES.

Alkylation of tetrabutylammonium dihydrogenophosphate by terpenic allylic sulphonium salts give the corresponding primary terpenic allylic phosphates in fair to moderate yields, without complex procedures of purification.The catalysis of the reaction by cuprous ion leads to the isolation of tertiary allylic phosphates.