55740-89-1Relevant academic research and scientific papers
Hantzsch ester triggered metal-free cascade approach to isoindolinones
Tian, Youping,Wei, Junmei,Wang, Meng,Li, Gaoqiang,Xu, Feng
, p. 1866 - 1870 (2018/04/14)
Disclosed herein is an expedient synthesis of biologically important isoindolinone derivatives from reactions of 2-formylbenzoic acids with various amines. This method operates via a deliberately designed catalyst-free tandem reductive amination/cyclization cascade event triggered by a transfer hydrogenation process with easily available Hantzsch ester as the organic hydride source. The ease of operation, mild reaction conditions, facile accessibility of the starting materials, and easy scalability of the current method distinguish it from the other precedent protocols, thus enable it a practical approach to the syntheses of valuable isoindolinone-incorporated drugs.
An Efficient Entry to syn- and anti-Selective Isoindolinones via an Organocatalytic Direct Mannich/Lactamization Sequence
Bisai, Vishnumaya,Unhale, Rajshekhar A.,Suneja, Arun,Dhanasekaran, Sivasankaran,Singh, Vinod K.
supporting information, p. 2102 - 2105 (2015/05/13)
(Chemical Equation Presented) An organocatalytic direct Mannich-lactamization sequence for the syntheses of pharmacologically important enantioenriched isoindolinones is reported. The method utilizes simple α-amino acids to deliver syn- and anti- selectiv
Ni(II)-Catalyzed Highly Stereo- and Regioselective Syntheses of Isoindolinones and Isoquinolinones from in Situ Prepared Aldimines Triggered by Homoallylation/Lactamization Cascade
Karmakar, Raju,Suneja, Arun,Bisai, Vishnumaya,Singh, Vinod K.
supporting information, p. 5650 - 5653 (2015/12/11)
An efficient route to isoindolinones and isoquinolinones has been achieved via a domino Ni-catalyzed homoallylation/lactamization from in situ prepared imines, derived from o-formyl benzoates and o-formyl arylacetates, with conjugated dienes promoted by diethylzinc. The reaction proceeds smoothly at room temperature for a variety of aldehydes, amines, and dienes. The method involves one C-C and two C-N bond forming events under operationally simple conditions.
SYNTHESIS OF 2-ARYL-3-CYANOPHTHALIMIDINES AND RELATED ANALOGS
Baum, Jonathan S.,Staveski, Mark M.
, p. 2283 - 2292 (2007/10/02)
A series of novel 3-cyano- and related 3-substituted phthalimidines have been synthesized from acyclic precursors, some of which were isolated.
