55745-88-5

Usage

Uses

Used in Pharmaceutical Development:
4-Methoxy-2-piperazin-1-ylpyrimidine is used as a potential drug candidate for the development of new medications. Its unique structure allows it to act as an antagonist or agonist at specific receptors, making it a valuable compound in the discovery and design of novel therapeutic agents.
Used in Chemical Research and Development:
In addition to its pharmaceutical applications, 4-Methoxy-2-piperazin-1-ylpyrimidine serves as a building block for the synthesis of more complex pharmaceutical compounds. Its versatile chemical properties make it a valuable tool in chemical research and development, enabling the exploration of new chemical entities and their potential applications in various fields.

InChI:InChI=1/C9H14N4O/c1-14-8-2-3-11-9(12-8)13-6-4-10-5-7-13/h2-3,10H,4-7H2,1H3

Upstream product

• 110-85-0 piperazine 
• 22536-63-6 2-chloro-4-methoxypyrimidine 

Downstream Products

• 1197356-70-9 4-methoxy-2-{4-[4-methyl-3-(pyridin-2-ylethynyl)benzoyl]piperazin-1-yl}pyrimidine 

Relevant academic research and scientific papers

Synthesis and biological activity of new 1-[4-(substituted)-piperazin-1- ylmethyl]-1H-benzotriazole

A new kind of benzotriazole derivatives has been designed and synthesised. The structures of all of the title compounds were characterised by 1H NMR, IR, MS and elemental analyses. Herbicidal activities of the benzotrizole derivatives were evaluated with barnyard grass and rape cup and KARI tests. The results showed that compounds exhibited weak herbicidal activities against barnyardgrass and rape and KARI enzyme.

Piperazine compounds and medicinal use thereof

The present invention relates to a piperazine compound of the formula wherein R1and R2are each hydrogen, halogen, lower alkyl, lower alkoxy, amino, substituted amino, nitro, hydroxy or cyano, R3, R4and R5are each hydrogen, halogen, lower alkyl, lower alkoxy, nitro, amino, substituted amino or hydroxy, R6and R7are each hydrogen, lower alkyl, lower alkyl substituted by halogen, aralkyl, acyl or lower acyl substituted by halogen, R8and R9are each hydrogen or lower alkyl, Y is lower alkylene and the like, and ring A is phenyl, pyrimidyl, thiazolyl, pyridyl, pyrazyl or imidazolyl, a pharmaceutically acceptable salt thereof and pharmaceutical agents containing these compounds. The compound of the present invention has superior TNF-α production inhibitory effect and/or IL-10 production promoting effect, and, since it is free of or shows only strikingly reduced expression of an effect on the central nervous system, the compound is useful as a highly safe and superior TNF-α production inhibitor an/or IL-10 production promoter and is useful as an agent for the prophylaxis or treatment of various diseases caused by abnormal TNF-α production, diseases curable with IL-10, such as chronic inflammatory diseases, acute inflammatory diseases, inflammatory diseases due to infection, autoimmune diseases, allergic diseases, and TNF-α mediated diseases.