55755-16-3

Basic information

• Product Name: 2-Methylphenethylamine
• Synonyms: 2-METHYLPHENETHYLAMINE;2-O-TOLYL-ETHYLAMINE;2-O-TOLYLETHANAMINE;AKOS 236-21;TIMTEC-BB SBB010061;RARECHEM AL BW 0206;2-Methylphenethylamine97%;2-Methylphenethylamine ,98%
• CAS NO: 55755-16-3
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 135.21
• Mol File: 55755-16-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 116°C (estimate)
• Boiling Point: 97°C 5mm
• Flash Point: 92.5 °C
• Appearance: Clear colorless/Liquid
• Density: 0,96 g/cm3
• Vapor Pressure: 0.105mmHg at 25°C
• Refractive Index: 1.534-1.536
• PKA: 9.91±0.10(Predicted)
• Water Solubility: Not miscible or difficult to mix with water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-Methylphenethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylphenethylamine(55755-16-3)
• EPA Substance Registry System: 2-Methylphenethylamine(55755-16-3)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-52-41-37/38
• Safety Statements: 45-36/37/39-26-39
• RIDADR: 2735
• HazardClass: CORROSIVE
• Hazardous Substances Data: 55755-16-3(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

It is employed as intermediate for pharmaceutical and organic synthesis

InChI:InChI=1/C9H13N/c1-8-4-2-3-5-9(8)6-7-10/h2-5H,6-7,10H2,1H3

Upstream product

• 611-15-4 1-methyl-2-vinyl-benzene 
• 529-20-4 2-methylphenyl aldehyde 
• 552-45-4 1-chloromethyl-2-methylbenzene 
• 64-17-5 ethanol 
• 22364-68-7 2-tolylmethylnitrile 
• 28638-59-7 methyl-2 β-nitrostyrene 
• 103028-79-1 3-o-tolyl-propionic acid amide 

Downstream Products

• 1021164-87-3 2-(2,6-dichloro-phenyl)-benzooxazole-6-carboxylic acid (2-o-tolyl-ethyl)-amide 
• 171880-39-0 4-acetoxy-5-methylisoquinoline-1-carboxaldehyde thiosemicarbazone 
• 72678-15-0 1,5-dimethylisoquinoline 
• 947304-09-8 C₃₀H₄₃N₃O₃ 
• 947303-96-0 C₁₈H₂₈N₂O₂ 
• 736054-82-3 3-aminomethyl-N-(2-o-tolyl-ethyl)-benzamide 
• 147410-32-0 (2-o-tolylethyl)carbamic acid tert-butyl ester 
• 171880-36-7 N-(2-methyl-phenethyl)-acetamide 

Relevant articles and documents

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

Fluorous dimethyl sulfide: A convenient, odorless, recyclable borane carrier

(matrix presented) Borane gas and 2-(perfluorooctyl)ethyl methyl sulfide form a solid comprised of an approximately 1:1 mixture (fluorous BMS) of sulfide and the corresponding sulfide-borane. Fluorous BMS permits hydroboration of alkenes in a dichloromethane/perfluorinated hydrocarbon mixture with subsequent recycling of the fluorous sulfide by fluorous extraction. The use of fluorous BMS in the asymmetric reduction of ketones catalyzed by a chiral oxaborolidine catalyst, and in the reduction of other functional groups, is also reported.

Process for the preparation of (8As,12AS,13AS)-decahydroisoquino ((2,1-G) (1,6)-naphthyridin-8-one derivatives

The invention provides a process for preparing single enantiomers of compounds represented by the formula: STR1 and chiral acid addition salts thereof; wherein: X and Y are independently hydrogen; lower alkyl; lower alkoxy; or halo; or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy; which includes reduction of a compound represented by the formula: STR2 to give a mixture of stereoisomers represented by the formula: STR3 wherein each wavy line independently represents a bond in either the α or β position; followed by dissolving the mixture of stereoisomers and a chiral resolving acid in a suitable solvent and allowing the solution to crystallize, giving a salt of the desired enantiomer.