55760-05-9Relevant academic research and scientific papers
Prostaglandins and congeners. XXII. Synthesis of 11-substituted derivatives of 11-de-oxyprostaglandins E1 and E2. Potential bronchodilators
Floyd,Schaub,Siuta,et al.
, p. 903 - 913 (2007/10/02)
The interesting bronchodilator activity of l-11-deoxy-11α-[(2-hydroxyethyl)thiolprostaglandin E2 methyl ester (3a) is described. The preparation of 3a and its analogues by Michael-type additions to various members of the PGA series or by total synthesis using the lithiocuprate conjugate addition process is also described. Structure-activity relationships in this series are discussed.
