55765-52-1

Upstream product

• 14366-66-6 1-chloro-4-[(3-chloropropyl)thio]benzene 
• 7722-84-1 dihydrogen peroxide 

Downstream Products

• 69563-24-2 1-Chloro-4-cyclopropanesulfinyl-benzene 
• 1227176-29-5 C₁₉H₂₉ClO₃S 
• 34930-61-5 1-[γ-(p-chlorophenylsulfinyl)-propyl]piperidine hydrochloride 
• 1238965-67-7 1-[3-[(4-Chlorophenyl)sulfinyl]propyl]-N-(3,4-difluorophenyl)-α-(4-fluorophenyl)-4-piperidinemethanamine 

Relevant academic research and scientific papers

Diastereoselective synthesis of tetrahydrofurans from Aryl 3-chloropropylsulfoxides and aldehydes

Carbanions of aryl 3-chloropropylsulfoxides react with nonenolizable aldehydes to give 2,3-disubstituted tetrahydrofurans. Deprotonation of the sulfoxides carried out in the presence of aldehydes results in the addition of the carbanions to the carbonyl group of the aldehydes, followed by 1,5-intramolecular substitution of the resulting aldol-type anion to produce the tetrahydrofuran ring. The 2-aryl and 3-arylsulfinyl substituents are always in trans relation, and the reaction proceeds with high diastereoselectivity also in respect to the chiral sulfur atom. The diastereoselectivity is attributed to the cyclic transition state of the aldol addition and increases when the aromatic ring of the sulfoxide contains electron-withdrawing substituents, whereas that of the aldehyde has electron-donating groups.

N-substituted alpha-arylazacycloalkylmethanamines and their use as cardiovascular agents

Novel compounds of the formula below wherein W is azetidine, pyrrolidine or piperidine, Q is a straight chain hydrocarbon radical of 1-4 carbons and may contain a double bond, and STR1 Ar is phenyl, pyridinyl or pyrimidinyl, a process for their preparation, and novel intermediates are disclosed. The novel compounds and the pharmaceutical compositions of this invention are useful in the treatment of hypertension, arrhythmias and angina.