55766-45-5Relevant academic research and scientific papers
Telescoped synthesis of C3-functionalized (E)-arylamidines using Ugi-Mumm and regiospecific quinazolinone rearrangements
Jaffett, Victor A.,Nerurkar, Alok,Cao, Xufeng,Guzei, Ilia A.,Golden, Jennifer E.
supporting information, p. 3118 - 3128 (2019/03/26)
An efficient four-step, six-transformation protocol was developed to afford bioactive N-alkyl- or N-arylamide (E)-arylamidines featuring strategic amidine C3 modifications which were inaccessible or low yielding by previous methods. This synthetic approac
Silver(I)-Catalyzed Regioselective Synthesis of Triazole Fused-1,5-Benzoxazocinones
Barve, Indrajeet J.,Thikekar, Tushar Ulhas,Sun, Chung-Ming
supporting information, p. 2370 - 2373 (2017/05/12)
An efficient and regioselective synthesis of novel 1,2,3-triazole-fused-1,5-benzoxazocinones through intramolecular cyclization of substituted ethynyl triazoyl benzoic acids was explored. A crucial precursor 5-iodo-1,2,3-triazole benzoate was obtained fro
3H-Azepines and Related Systems. Part 2. The Photolyses of Aryl Azides Bearing Electron-withdrawing Substituents
Purvis, Roger,Smalley, Robert K.,Suschitzky, Hans,Alkhader, Mohamed A.
, p. 249 - 254 (2007/10/02)
The photolyses of ortho-substituted aryl azides (o-XC6H4N3 where X = CONHNH2, CONHN=CHAr, NO2, CN, CF3, SO2OMe, SO2NH2, or SO2Ph) in methanol-tetrahydrofuran solution are described.With X = CF3 or CONHN=CHAr, 3-substituted 2-methoxy-3H-azepines are products, while in other cases polymeric products, amines or mixtures of isomeric azepines are obtained.The product from the photolysis of o-azidophenyl phenyl sulphoxide (X = SOPh) is identified tentatively (n.m.r. evidence) as 7-methoxy-2-phenylsulphinyl-3H-azepine.In contrast, methyl p-azidobenzoate and p-cyanophenyl azide yield the corresponding 5-substituted 2-methoxy-3H-azepines, whereas methyl m-azidobenzoate yields only methyl 2-methoxy-3H-azepine-6-carboxylate.Irradiation of methyl o-azidobenzoate in aqueous tetrahydrofuran gives 1,3-dihydro-3-methoxycarbonyl-2H-azepin-2-one.
