55769-33-0Relevant academic research and scientific papers
Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors
Bergman, Joel A.,Hahne, Kalub,Hrycyna, Christine A.,Gibbs, Richard A.
, p. 5616 - 5619 (2011/10/13)
Inhibition of isoprenylcysteine carboxyl methyltransferase (Icmt) offers a promising strategy for K-Ras driven cancers. We describe the synthesis and inhibitory activity of substrate-based analogs derived from several novel scaffolds. Modifications of bot
