55769-34-1Relevant academic research and scientific papers
Farnesyl diphosphate analogues with Aryl moieties are efficient alternate substrates for protein farnesyltransferase
Subramanian, Thangaiah,Pais, June E.,Liu, Suxia,Troutman, Jerry M.,Suzuki, Yuta,Leela Subramanian, Karunai,Fierke, Carol A.,Andres, Douglas A.,Spielmann, H. Peter
, p. 8307 - 8319 (2013/01/15)
Farnesylation is an important post-translational modification essential for the proper localization and function of many proteins. Transfer of the farnesyl group from farnesyl diphosphate (FPP) to proteins is catalyzed by protein farnesyltransferase (FTas
Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors
Bergman, Joel A.,Hahne, Kalub,Hrycyna, Christine A.,Gibbs, Richard A.
, p. 5616 - 5619 (2011/10/13)
Inhibition of isoprenylcysteine carboxyl methyltransferase (Icmt) offers a promising strategy for K-Ras driven cancers. We describe the synthesis and inhibitory activity of substrate-based analogs derived from several novel scaffolds. Modifications of bot
