55770-05-3

Upstream product

• 64-17-5 ethanol 
• 2856-63-5 2-Chlorophenylacetonitrile 

Downstream Products

• 151411-46-0 N-[3-(2-Chloro-6-fluorobenzyloxy)pyrid-2-yl]-2-chlorophenylacetamidine hydrochloride 
• 1470364-71-6 5-(o-chlorobenzyl)-4-m-chlorobenzyliden amino-2,4-dihydro-2H-1,2,4-triazol-3-one 
• 1470364-72-7 5-(o-chlorobenzyl)-4-m-bromo-4-fluorobenzyliden amino-2,4-dihydro-2H-1,2,4-triazol-3-one 
• 1470364-73-8 5-(o-chlorobenzyl)-4-p-nitrobenzyliden amino-2,4-dihydro-2H-1,2,4-triazol-3-one 
• 1616422-61-7 N'-[2-(2-chlorophenyl)ethanimidoyl]-2-phenylacetohydrazide 
• 1616422-76-4 N-[2-(2-chlorobenzyl)-4-(4-chlorophenyl)-1H-imidazol-1-yl]-2-phenylacetamide 
• 1616422-68-4 N-[2-(2-chlorobenzyl)-4-phenyl-1H-imidazol-1-yl]-2-phenylacetamide 
• 1443550-80-8 5,6-dichloro-2-(2-chlorobenzyl)-1H-benzimidazole 
• 1443550-91-1 2-{5,6-dichloro-2-[(o-chlorophenyl)methyl]-1,3-diaza-1H-inden-1-yl}-1-hydrazino-1-ethanone 
• 1443550-85-3 methyl 2-[5,6-dichloro-2-(2-chlorobenzyl)-1H-benzimidazol-1-yl]acetate 
• 877315-80-5 3-o-chlorobenzyl-4-amino-4,5-dihydro-1H-1,2,4-triazole-5-one 

Relevant academic research and scientific papers

Synthesis of Some Novel 2-Substitutedbenzyl-(4)7-phenyl-1H-benzo[d]imidazoles in Mild Conditions as Potent Anti-Tyrosinase and Antioxidant Agents

Novel 2-substitutedbenzyl-4(7)-phenyl-1H-benzo[d]imidazole compounds were synthesized and characterized. Although 2a and 2b were reported previously in the literature, 11 compounds were synthesized (nine of them were newly synthesized) and the tyrosinase inhibitory effects and antioxidant activities of these compounds were studied for the first time. All of the synthesized compounds displayed certain inhibitory effects on tyrosinase, with IC50 values ranging from 37.86 ± 0.24 to 75.81 ± 2.49 μM. Among the compounds, 2j exhibited similar tyrosinase inhibitory effect (IC50 = 37.86 ± 0.24 μM) to the positive control, kojic acid (IC50 = 21.93 ± 0.11 μM). Kinetic studies revealed it to act as non-competitive tyrosinase inhibitor with a Ki value of 50.2 μM. The antioxidant activities of the compounds were investigated by using in vitro antioxidant assays, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP). All of these results indicated that the compounds might have potential application as tyrosinase inhibitors.

Efficient microwave assisted synthesis of some new benzimidazoles containing the mebendazole nucleus

A simple and practical method has been developed for the synthesis of benzimidazoles containing the biological active mebendazole nucleus. Iminoester hydrochlorides of phenylacetic acids were used as intermediates in the reaction with 3,4-diaminobenzophen

Microwave-assisted synthesis of some 5(6)-nitro-1H-benzimidazoles and their hydrazide derivatives

A series of 5(6)-nitro-1H-benzimidazole and their hydrazide derivatives were synthesized starting from iminoester hydrochloride and 4-nitro-o- phenylenediamine under microwave irradiation. The structure of all synthesized compounds was confirmed by IR, s

Microwave-assisted synthesis of some new benzylidenamino compounds and potentiometric determination of their pKa

A growing body of literature has shown the effectiveness of using microwaves in chemical reactions. The aim of this study is to demonstrate a rapid and highly efficient synthesis of some new benzylidenamino compounds (4a-f) via microwave heating using a m

Cyanoamidine P2X7 antagonists for the treatment of pain

Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.

Synthesis of 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their isatin-3-imine derivatives

Iminoester hydrochlorides 1 have been synthesized. These compounds were then converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new series of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared. Finally a set

[(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders

The present invention relates to N-pyridylamidine and N-pyridylguanidine derivatives of general formula (I) in which: Ar1 is an optionally substituted phenyl ring; Ar2 is an optionally substituted phenyl ring; R1 is hydrogen or C1-4 alkyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C1-4 alkyl; R4 is hydrogen, halogen, C1-6 alkyl or C1-6 alkoxy; X is CH2 or NR5, and R5 is hydrogen or C1-4 alkyl, and the salts thereof, and their use in therapy as gastric acid secretion inhibitors.