55774-12-4Relevant academic research and scientific papers
Electrochemical Synthesis of Benzimidazoles via Dehydrogenative Cyclization of Amidines
Zhao, Huai-Bo,Zhuang, Jin-Liang,Xu, Hai-Chao
, p. 1692 - 1695 (2021/03/01)
The development of efficient and sustainable methodologies for the synthesis of N-heterocycles is a constant focus of organic synthesis. Herein an electrochemical method is reported for the synthesis of benzimidazoles through dehydrogenative cyclization of easily available N-aryl amidines. The reactions were conducted under simple constant current conditions in an undivided cell without need for catalysts, chemical oxidants, or additives, and produced H2 as the only theoretical byproduct.
C-H functionalization/C-N bond formation: Copper-catalyzed synthesis of benzimidazoles from amidines
Brasche, Gordon,Buchwald, Stephen L.
, p. 1932 - 1934 (2008/12/22)
(Chemical Equation Presented) Copper closes the ring: Benzimidazoles are synthesized from amidines through a copper-catalyzed C-H functionalization/ C-N bond-forming process. The method tolerates a broad range of functional groups and provides the benzimidazoles in up to 89% yield. Best results are obtained by using 15 mol% Cu(OAc)2, 2-5 equivalents of HOAc as additive, and oxygen as the stoichiometric reoxidant (see scheme).
Basicity of azoles: VII. Protonation and conformations of 2-(2-pyridyl)benzimidazoles by UV spectral data
Turchaninov,Vokin,Baikalova,Shulunova
, p. 583 - 595 (2007/10/03)
Absorption bands in the UV spectra of 2-aryl(hetaryl)benzimidazoles were assigned on the basis of AM1(CI) semiempirical calculations. The energy gap between the S1, and S2 states of these compounds depends on the molecular conformati
